TY - JOUR
T1 - Structure and Absolute Configuration of Abietane Diterpenoids from Salvia clinopodioides
T2 - Antioxidant, Antiprotozoal, and Antipropulsive Activities
AU - Bustos-Brito, Celia
AU - Joseph-Nathan, Pedro
AU - Burgueño-Tapia, Eleuterio
AU - Martínez-Otero, Diego
AU - Nieto-Camacho, Antonio
AU - Calzada, Fernando
AU - Yépez-Mulia, Lilian
AU - Esquivel, Baldomero
AU - Quijano, Leovigildo
N1 - Publisher Copyright:
© 2019 American Chemical Society and American Society of Pharmacognosy.
PY - 2019/5/24
Y1 - 2019/5/24
N2 - The aerial parts of Salvia clinopodioides afforded abietanes 1a, 2a, and 3 (clinopodiolides A-C), two of which possess an unusual lactol moiety at C-19-C-20, together with an icetexane named clinopodiolide D (4a). Their structures were established by spectroscopic means, mainly 1H and 13C NMR, including 1D and 2D homo- and heteronuclear experiments. The antioxidant, antiprotozoal, and antidiarrheal effects of the isolates were evaluated. Compounds 2a and 3 showed better effects than α-tocopherol in the inhibition of lipid peroxidation with IC50 (μM) = 5.9 ± 0.1 and 2.7 ± 0.2, respectively, and moderate activity in the DPPH assay. All tested compounds showed moderate antiamoebic and antigiardial activity, as well as a good antipropulsive effect.
AB - The aerial parts of Salvia clinopodioides afforded abietanes 1a, 2a, and 3 (clinopodiolides A-C), two of which possess an unusual lactol moiety at C-19-C-20, together with an icetexane named clinopodiolide D (4a). Their structures were established by spectroscopic means, mainly 1H and 13C NMR, including 1D and 2D homo- and heteronuclear experiments. The antioxidant, antiprotozoal, and antidiarrheal effects of the isolates were evaluated. Compounds 2a and 3 showed better effects than α-tocopherol in the inhibition of lipid peroxidation with IC50 (μM) = 5.9 ± 0.1 and 2.7 ± 0.2, respectively, and moderate activity in the DPPH assay. All tested compounds showed moderate antiamoebic and antigiardial activity, as well as a good antipropulsive effect.
UR - http://www.scopus.com/inward/record.url?scp=85066135312&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.8b00952
DO - 10.1021/acs.jnatprod.8b00952
M3 - Artículo
C2 - 31063376
SN - 0163-3864
VL - 82
SP - 1207
EP - 1216
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -