TY - JOUR
T1 - Structure-Activity Relationships of Aromadendranes in Uterus-Relaxant Activity
AU - Pérez-Hernández, Nury
AU - Ponce-Monter, Hector
AU - Ortiz, Mario I.
AU - Cariño-Cortés, Raquel
AU - Joseph-Nathan, Pedro
PY - 2009/12
Y1 - 2009/12
N2 - Aromadendranes belong to a class of sesquiterpenes present in higher plant essential oils and marine animals. Although the biological activities include antifungal, antibacterial, antiviral, plant growth regulatory, antifeedant, repellent and cytotoxic, there is only one prec-edent for spasmolytic effects. In a previous report we have shown that the aromadendrene molecule known as spathulenol, isolated from Lepechinia caulescens, effi ciently relaxes rat uterus rings and therefore in the present work we describe structure-activity relationships of thirteen aromadendranes, most of them having the trans-fused perhydroazulene skeleton, with spasmolytic activity.
AB - Aromadendranes belong to a class of sesquiterpenes present in higher plant essential oils and marine animals. Although the biological activities include antifungal, antibacterial, antiviral, plant growth regulatory, antifeedant, repellent and cytotoxic, there is only one prec-edent for spasmolytic effects. In a previous report we have shown that the aromadendrene molecule known as spathulenol, isolated from Lepechinia caulescens, effi ciently relaxes rat uterus rings and therefore in the present work we describe structure-activity relationships of thirteen aromadendranes, most of them having the trans-fused perhydroazulene skeleton, with spasmolytic activity.
KW - Aromadendranes
KW - Structure-Activity Relationships
KW - Uterus-Relaxant Activity
UR - http://www.scopus.com/inward/record.url?scp=74049112235&partnerID=8YFLogxK
U2 - 10.1515/znc-2009-11-1214
DO - 10.1515/znc-2009-11-1214
M3 - Artículo
SN - 0939-5075
VL - 64
SP - 840
EP - 846
JO - Zeitschrift fur Naturforschung - Section C Journal of Biosciences
JF - Zeitschrift fur Naturforschung - Section C Journal of Biosciences
IS - 11-12
ER -