Stress proteins in the pathogenesis of spondyloarthritis

José Pablo Romero-López, María Lilia Domínguez-López, Rubén Burgos-Vargas, Ethel García-Latorre

Research output: Contribution to journalScientific review

Abstract

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Spondyloarthritis is an autoinflammatory rheumatic disease in which arthritis and osteoproliferation lead the patients who suffer from it to chronic disability. This disease is associated with the expression of class I MHC molecule HLA-B27, which tends to be misfolded in the endoplasmic reticulum and, therefore, expressed in aberrant forms. This phenomena lead to endoplasmic reticulum stress, which in time, evokes a whole response to cellular injury. Under these conditions, the molecules involved in restoring cell homeostasis play a key role. Such is the case of the “heat-shock proteins”, which usually regulate protein folding, but also have important immunomodulatory functions, as well as some roles in tissue modeling. In this review, we attempt to summarize the involvement of cell stress and heat-shock proteins in the homeostatic disturbances and pathological conditions associated with this disease.
Original languageAmerican English
Pages (from-to)595-604
Number of pages534
JournalRheumatology International
DOIs
StatePublished - 10 Apr 2019

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Heat-Shock Proteins
HLA-B27 Antigen
Endoplasmic Reticulum Stress
Protein Folding
Rheumatic Diseases
Endoplasmic Reticulum
Arthritis
Germany
Homeostasis
Wounds and Injuries

Cite this

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title = "Stress proteins in the pathogenesis of spondyloarthritis",
abstract = "{\circledC} 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Spondyloarthritis is an autoinflammatory rheumatic disease in which arthritis and osteoproliferation lead the patients who suffer from it to chronic disability. This disease is associated with the expression of class I MHC molecule HLA-B27, which tends to be misfolded in the endoplasmic reticulum and, therefore, expressed in aberrant forms. This phenomena lead to endoplasmic reticulum stress, which in time, evokes a whole response to cellular injury. Under these conditions, the molecules involved in restoring cell homeostasis play a key role. Such is the case of the “heat-shock proteins”, which usually regulate protein folding, but also have important immunomodulatory functions, as well as some roles in tissue modeling. In this review, we attempt to summarize the involvement of cell stress and heat-shock proteins in the homeostatic disturbances and pathological conditions associated with this disease.",
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Stress proteins in the pathogenesis of spondyloarthritis. / Romero-López, José Pablo; Domínguez-López, María Lilia; Burgos-Vargas, Rubén; García-Latorre, Ethel.

In: Rheumatology International, 10.04.2019, p. 595-604.

Research output: Contribution to journalScientific review

TY - JOUR

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AU - Romero-López, José Pablo

AU - Domínguez-López, María Lilia

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AU - García-Latorre, Ethel

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AB - © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Spondyloarthritis is an autoinflammatory rheumatic disease in which arthritis and osteoproliferation lead the patients who suffer from it to chronic disability. This disease is associated with the expression of class I MHC molecule HLA-B27, which tends to be misfolded in the endoplasmic reticulum and, therefore, expressed in aberrant forms. This phenomena lead to endoplasmic reticulum stress, which in time, evokes a whole response to cellular injury. Under these conditions, the molecules involved in restoring cell homeostasis play a key role. Such is the case of the “heat-shock proteins”, which usually regulate protein folding, but also have important immunomodulatory functions, as well as some roles in tissue modeling. In this review, we attempt to summarize the involvement of cell stress and heat-shock proteins in the homeostatic disturbances and pathological conditions associated with this disease.

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