TY - GEN
T1 - Stage determination of breast cancer biopsy using raman spectroscopy and multivariate analysis
AU - González-Solís, J. L.
AU - Aguiñaga-Serrano, B. I.
AU - Martínez-Espinosa, J. C.
AU - Oceguera-Villanueva, A.
PY - 2011
Y1 - 2011
N2 - The use of Raman spectroscopy to analyze biopsy biochemistry and hence distinguish between the breast cancer stages was investigated. The biopsy samples were obtained from 13 patients who were clinically diagnosed with breast cancer. A preliminary diagnosis of some breast cancer patient was realized by pathologist of the Cancer Institute. The biopsies were put under the microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with a NIR 830 nm laser. It is shown that the breast cancer stages of biopsies can be discriminated when the Principal Components Analysis (PCA) is applied to their Raman spectra. Ratios of some band intensities were analyzed and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be an excellent technique for stage determination of breast cancer.
AB - The use of Raman spectroscopy to analyze biopsy biochemistry and hence distinguish between the breast cancer stages was investigated. The biopsy samples were obtained from 13 patients who were clinically diagnosed with breast cancer. A preliminary diagnosis of some breast cancer patient was realized by pathologist of the Cancer Institute. The biopsies were put under the microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with a NIR 830 nm laser. It is shown that the breast cancer stages of biopsies can be discriminated when the Principal Components Analysis (PCA) is applied to their Raman spectra. Ratios of some band intensities were analyzed and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be an excellent technique for stage determination of breast cancer.
KW - Biopsy
KW - Breast cancer
KW - Principal components analysis
KW - Raman spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=80055044886&partnerID=8YFLogxK
U2 - 10.1063/1.3626909
DO - 10.1063/1.3626909
M3 - Contribución a la conferencia
AN - SCOPUS:80055044886
SN - 9780735409224
T3 - AIP Conference Proceedings
SP - 33
EP - 40
BT - Advances in Laserology - Selected Papers of Laser Florence 2010
T2 - Annual Congress of the International Academy Laser Medicine and Surgery, Laser Florence 2010
Y2 - 5 November 2010 through 6 November 2010
ER -