Stage determination of breast cancer biopsy using raman spectroscopy and multivariate analysis

J. L. González-Solís, B. I. Aguiñaga-Serrano, J. C. Martínez-Espinosa, A. Oceguera-Villanueva

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Scopus citations

Abstract

The use of Raman spectroscopy to analyze biopsy biochemistry and hence distinguish between the breast cancer stages was investigated. The biopsy samples were obtained from 13 patients who were clinically diagnosed with breast cancer. A preliminary diagnosis of some breast cancer patient was realized by pathologist of the Cancer Institute. The biopsies were put under the microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with a NIR 830 nm laser. It is shown that the breast cancer stages of biopsies can be discriminated when the Principal Components Analysis (PCA) is applied to their Raman spectra. Ratios of some band intensities were analyzed and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be an excellent technique for stage determination of breast cancer.

Original languageEnglish
Title of host publicationAdvances in Laserology - Selected Papers of Laser Florence 2010
Subtitle of host publicationThe 50th Birthday of Laser Medicine World
Pages33-40
Number of pages8
DOIs
StatePublished - 2011
Externally publishedYes
EventAnnual Congress of the International Academy Laser Medicine and Surgery, Laser Florence 2010 - Florence, Italy
Duration: 5 Nov 20106 Nov 2010

Publication series

NameAIP Conference Proceedings
Volume1364
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceAnnual Congress of the International Academy Laser Medicine and Surgery, Laser Florence 2010
Country/TerritoryItaly
CityFlorence
Period5/11/106/11/10

Keywords

  • Biopsy
  • Breast cancer
  • Principal components analysis
  • Raman spectroscopy

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