Sindbis virus-based measles DNA vaccines protect cotton rats against respiratory measles: Relevance of antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and Th1-type cytokines as correlates of immunity

Marcela F. Pasetti, Karina Ramirez, Aldo Resendiz-Albor, Jeffrey Ulmer, Eileen M. Barry, Myron M. Levine

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Measles remains an important cause of pediatric morbidity and mortality in developing countries, especially among infants who are too young to receive the current licensed live attenuated measles vaccine. We developed two Sindbis virus DNA vaccines encoding the measles virus hemagglutinin (pMSIN-H) and fusion proteins (pMSINH-FdU) and examined their immunogenicities and protective efficacies when administered alone or followed by the live measles virus vaccine in cotton rats. Neutralizing antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and gamma interferon-secreting T cells developed after priming and increased after boosting. pMSIN-H priming conferred 100% protection against pulmonary measles, whereas pMSINH-FdU protected only in conjunction with the live measles virus vaccine boost. Copyright © 2009, American Society for Microbiology.
Original languageAmerican English
Pages (from-to)2789-2794
Number of pages6
JournalJournal of Virology
DOIs
StatePublished - 1 Mar 2009
Externally publishedYes

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