TY - JOUR
T1 - Simulation of bronchial airflow in copd patients
AU - Salcedo-Hernandez, L. F.
AU - Torres-Sanmiguel, C. R.
AU - Urriolagoitia-Sosa, G.
AU - Miguel, G. P.Torres San
AU - Aguilarperez, L. A.
AU - Urriolagoita-Calderon, G.
N1 - Publisher Copyright:
© 2020 Salcedo-Hernandez et al.
PY - 2020
Y1 - 2020
N2 - Aim: This research tackles the problem of assessing airflow inside both a healthy and a COPD bronchus ramification, by a Finite Element Method (FEM) computational mode. Background: Chronic Obstructive Pulmonary Disease (COPD) is considered the third leading cause of death worldwide, smoking being the most common risk factor. In the case of emphysema, the appearance of bullae in the upper and middle lobes is frequent. Objective: Bullae tend to increase their size progressively with time, severely clogging bronchi. In this research, bullae with different sizes are modelled as semi-spheres located at the internal wall of a 3D tomographic-based bronchi model. Methods: Several numerical analyses were performed by applying fluid interaction focused on the behaviour of flow through a fifth generations bronchus bifurcation in different cases and degrees of the advance of COPD. Results: The outcome provides the gradients of flow speed and pressure within the bronchus ramification in the considered cases. Conclusion: The methodology herein proposed is applicable to determine the airflow within any patient’s bronchus bifurcation were bullae appear, and thereby to assess and improve the design of custom treatments.
AB - Aim: This research tackles the problem of assessing airflow inside both a healthy and a COPD bronchus ramification, by a Finite Element Method (FEM) computational mode. Background: Chronic Obstructive Pulmonary Disease (COPD) is considered the third leading cause of death worldwide, smoking being the most common risk factor. In the case of emphysema, the appearance of bullae in the upper and middle lobes is frequent. Objective: Bullae tend to increase their size progressively with time, severely clogging bronchi. In this research, bullae with different sizes are modelled as semi-spheres located at the internal wall of a 3D tomographic-based bronchi model. Methods: Several numerical analyses were performed by applying fluid interaction focused on the behaviour of flow through a fifth generations bronchus bifurcation in different cases and degrees of the advance of COPD. Results: The outcome provides the gradients of flow speed and pressure within the bronchus ramification in the considered cases. Conclusion: The methodology herein proposed is applicable to determine the airflow within any patient’s bronchus bifurcation were bullae appear, and thereby to assess and improve the design of custom treatments.
KW - Airflow
KW - Biomechanics
KW - Bullae
KW - COPD
KW - FEM
KW - TAC
UR - http://www.scopus.com/inward/record.url?scp=85096767130&partnerID=8YFLogxK
U2 - 10.2174/1874120702014010020
DO - 10.2174/1874120702014010020
M3 - Artículo
AN - SCOPUS:85096767130
SN - 1874-1207
VL - 14
SP - 20
EP - 27
JO - Open Biomedical Engineering Journal
JF - Open Biomedical Engineering Journal
IS - 1
ER -