Silica from rice husks employed as drug delivery for folic acid

Mercedes Salazar Hernández, Carmen Salazar Hernández, Alfredo Gutiérrez Fuentes, Enrique Elorza, Marcelino Carrera-Rodríguez, María J. Puy Alquiza

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Abstract

Silica was obtained from rice husk, this type of silica is also known as SiO2-rice, was investigated as drug delivery for the folic acid. The SiO2-rice was obtained from calcinations at 600 °C and its textural properties were compared with mesoporous silica (MS). The maximum folic acid adsorption on SiO2-rice was at the 18 % weight, while MS adsorbs 19 % weight. An important pH effect on the drug released was observed; both silicas released around 35 % of acid folic at pH 7, while at pH 3 only 3 % of the drug was released. Differential Thermal Analyzer analysis suggests that the folic acid was not crystallized into the porous of the silica; therefore, it is possible that the drug was trapped within the complex network of pores preventing their full release. However, the drug released for 400 μg of folic acid, a commercial dose, indicated that until 93 % of drug could be released for the silicas at pH of 5.5; a minor desorption was observed by commercial tablet. © 2014 Springer Science+Business Media New York.
Original languageAmerican English
Pages (from-to)514-521
Number of pages461
JournalJournal of Sol-Gel Science and Technology
DOIs
StatePublished - 1 Jan 2014

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