TY - JOUR
T1 - Seroprevalence of pandemic A(H1N1) pmd09 virus antibodies in Mexican health care workers before and after vaccination
AU - Aguilar-Madrid, Guadalupe
AU - Castelán-Vega, Juan Arturo
AU - Juárez-Pérez, Cuauhtémoc Arturo
AU - Ribas-Aparicio, Rosa María
AU - Estrada-García, Iris
AU - Baltierra-Jasso, Laura
AU - Cervantes-Servín, Nicté
AU - Méndez-Ortega, Vanessa
AU - Haro-García, Luis C.
AU - Sánchez-Román, Francisco Raúl
AU - Ortiz-Navarrete, Vianney
AU - Fabila-Castillo, Luis H.
AU - Magaña-Hernández, Anastasia
AU - Chávez-Negrete, Adolfo
AU - Salamanca-Gómez, Fabio Abdel
AU - Jiménez-Alberto, Alicia
N1 - Publisher Copyright:
© 2015 IMSS.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Background and Aims: In April 2009, a new strain of influenza A(H1N1) was identified in Mexico and in the U.S. In June 2009, WHO declared this a pandemic. Health care workers constituted a risk group for their close contact with infected individuals. The aim was to estimate seropositivity for A(H1N1)pdm09 in health staff at the Instituto Mexicano del Seguro Social. Methods: A two-stage cross-sectional study, before and after vaccination in the same workers, was performed on a random sample of health-care workers. A socio-occupational questionnaire was applied and serum antibodies against influenza A(H1N1)pdm09 were determined through neutralization of retroviral pseudotypes; two logistic regression models for both were constructed. Results: The average (median/mean) age of 1378 participants from 13 work centers was 41.7 years and 68.7% (947) were women. Seroprevalence for the first stage was 26.5% (365) (7.4-43%) vs. 20.8% (11) in a control group from the blood bank; for the second stage, the vaccinated group was 33% (215) (18.2-47%) and 27% (196) (11.6-50%) for the unvaccinated group. In regression models, seropositivity was associated with occupational exposure to suspected influenza infected patients, being physicians, and being vaccinated. Conclusions: Seropositivity against pandemic virus is similar to what was reported, both for vaccinated (2.8-40.9%) and unvaccinated (18.8-64.7%). Low seroprevalence in the vaccinated group indicates that between 67% and 73% were susceptible to infection. Given the relatively low vaccine-induced seropositivity, it is imperative to increase, hygiene and safety for health staff and at-risk populations, and strengthen epidemiological surveillance.
AB - Background and Aims: In April 2009, a new strain of influenza A(H1N1) was identified in Mexico and in the U.S. In June 2009, WHO declared this a pandemic. Health care workers constituted a risk group for their close contact with infected individuals. The aim was to estimate seropositivity for A(H1N1)pdm09 in health staff at the Instituto Mexicano del Seguro Social. Methods: A two-stage cross-sectional study, before and after vaccination in the same workers, was performed on a random sample of health-care workers. A socio-occupational questionnaire was applied and serum antibodies against influenza A(H1N1)pdm09 were determined through neutralization of retroviral pseudotypes; two logistic regression models for both were constructed. Results: The average (median/mean) age of 1378 participants from 13 work centers was 41.7 years and 68.7% (947) were women. Seroprevalence for the first stage was 26.5% (365) (7.4-43%) vs. 20.8% (11) in a control group from the blood bank; for the second stage, the vaccinated group was 33% (215) (18.2-47%) and 27% (196) (11.6-50%) for the unvaccinated group. In regression models, seropositivity was associated with occupational exposure to suspected influenza infected patients, being physicians, and being vaccinated. Conclusions: Seropositivity against pandemic virus is similar to what was reported, both for vaccinated (2.8-40.9%) and unvaccinated (18.8-64.7%). Low seroprevalence in the vaccinated group indicates that between 67% and 73% were susceptible to infection. Given the relatively low vaccine-induced seropositivity, it is imperative to increase, hygiene and safety for health staff and at-risk populations, and strengthen epidemiological surveillance.
KW - Health care workers
KW - Influenza A(H1N1)pdm09
KW - Retroviral pseudotypes
KW - Seroprevalence
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=84928746781&partnerID=8YFLogxK
U2 - 10.1016/j.arcmed.2015.03.001
DO - 10.1016/j.arcmed.2015.03.001
M3 - Artículo
C2 - 25796508
SN - 0188-4409
VL - 46
SP - 154
EP - 163
JO - Archives of Medical Research
JF - Archives of Medical Research
IS - 2
ER -