TY - JOUR
T1 - Sensory-motor response elicited by first time intraoral administered ethanol after trigeminal neuropathic injury
AU - Andrade-Gonzalez, R. D.
AU - Perrusquia-Hernández, E.
AU - Zepeda-Reyes, K. I.
AU - Hernandez Campos, M. E.
AU - Perez-Martinez, I. O.
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/9
Y1 - 2022/9
N2 - Recent findings have shown a relationship between alcohol use disorders (AUD) and chronic pain. Preclinical models have demonstrated that chronic pain, including trigeminal nerve injury, increases ethanol consumption throughout extended administration periods. Nevertheless, it remains unclear whether chronic pain induces a greater susceptibility to developing AUD by altering motor control consumption regardless of the symptomatology of neuropathic pain, and whether sex influences this susceptibility. We used a former prolonged pain experience model induced by a constriction of the mental nerve (mNC) to answer this question. We analyzed ethanol consumption in a short-access protocol to reduce the post-ingestional effects and compared licking microstructure between groups. The constriction of the mental nerve induced evoked and spontaneous pain and reduction in the hedonic value of sucrose. The differences in alcohol consumption were not reflective of the former prolonged pain experience. Female mice showed a more efficient dynamic of consumption of alcohol, reflected in a long burst of licking and a less variable licking rate within a cluster.
AB - Recent findings have shown a relationship between alcohol use disorders (AUD) and chronic pain. Preclinical models have demonstrated that chronic pain, including trigeminal nerve injury, increases ethanol consumption throughout extended administration periods. Nevertheless, it remains unclear whether chronic pain induces a greater susceptibility to developing AUD by altering motor control consumption regardless of the symptomatology of neuropathic pain, and whether sex influences this susceptibility. We used a former prolonged pain experience model induced by a constriction of the mental nerve (mNC) to answer this question. We analyzed ethanol consumption in a short-access protocol to reduce the post-ingestional effects and compared licking microstructure between groups. The constriction of the mental nerve induced evoked and spontaneous pain and reduction in the hedonic value of sucrose. The differences in alcohol consumption were not reflective of the former prolonged pain experience. Female mice showed a more efficient dynamic of consumption of alcohol, reflected in a long burst of licking and a less variable licking rate within a cluster.
KW - Alcohol use disorders
KW - Ethanol consumption
KW - Licking microstructure
KW - Orofacial neuropathic pain
KW - Trigeminal injury
UR - http://www.scopus.com/inward/record.url?scp=85133906192&partnerID=8YFLogxK
U2 - 10.1016/j.alcohol.2022.06.001
DO - 10.1016/j.alcohol.2022.06.001
M3 - Artículo
C2 - 35714863
AN - SCOPUS:85133906192
SN - 0741-8329
VL - 103
SP - 9
EP - 17
JO - Alcohol
JF - Alcohol
ER -