TY - CHAP
T1 - Searching Epitope-Based Vaccines Using Bioinformatics Studies
AU - Martínez-Archundia, Marlet
AU - Ramírez-Salinas, G. Lizbeth
AU - García-Machorro, Jazmin
AU - Correa-Basurto, José
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022
Y1 - 2022
N2 - Epitope-based vaccines is one of the most recent methodologies applied in bioinformatics studies. This strategy consists of identifying regions of the protein (peptides or epitopes) which show antigen properties capable of stimulating the immune system against proteins from virus, bacteria, fungi, etc. This chapter describes a general procedure to identify epitopes to be used as epitope vaccine using bioinformatics methods including primary protein sequence analyses, epitope predictor, docking, and molecular dynamics simulations for the selection of T- and B-cell epitopes.
AB - Epitope-based vaccines is one of the most recent methodologies applied in bioinformatics studies. This strategy consists of identifying regions of the protein (peptides or epitopes) which show antigen properties capable of stimulating the immune system against proteins from virus, bacteria, fungi, etc. This chapter describes a general procedure to identify epitopes to be used as epitope vaccine using bioinformatics methods including primary protein sequence analyses, epitope predictor, docking, and molecular dynamics simulations for the selection of T- and B-cell epitopes.
KW - Conservative evolution
KW - Epitopes
KW - Promiscuity
KW - Super-types
KW - Surface exposition
UR - http://www.scopus.com/inward/record.url?scp=85121710931&partnerID=8YFLogxK
U2 - 10.1007/978-1-0716-1892-9_26
DO - 10.1007/978-1-0716-1892-9_26
M3 - Capítulo
C2 - 34918263
AN - SCOPUS:85121710931
T3 - Methods in Molecular Biology
SP - 471
EP - 479
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -
