SCE frequencies induced by ethanol, tequila and brandy in mouse bone marrow cells in vivo

A. Piña Calva; E. Madrigal-Bujaidar

doi:10.1016/0378-4274(93)90072-6

SCE frequencies induced by ethanol, tequila and brandy in mouse bone marrow cells in vivo

A. Piña Calva, E. Madrigal-Bujaidar

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The genotoxicity of ethanol, tequila and brandy was evaluated by scoring the frequency of sister chromatid exchanges (SCE) and determining the values of the average generation time (AGT). We studied four dosages of each substance i.p. inoculated into mice. The cytogenetic analysis was performed in bone marrow cells. The results showed that all three substances were weak genotoxicants. Tequila showed the strongest response followed by brandy and ethanol. None of them modified the cell proliferation kinetics as demonstrated by the AGT results.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Toxicology Letters
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(93)90072-6
State	Published - Jan 1993

Keywords

Brandy
Ethanol
Mouse bone marrow
Sister chromatid exchanges
Tequila

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10.1016/0378-4274(93)90072-6

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abstract = "The genotoxicity of ethanol, tequila and brandy was evaluated by scoring the frequency of sister chromatid exchanges (SCE) and determining the values of the average generation time (AGT). We studied four dosages of each substance i.p. inoculated into mice. The cytogenetic analysis was performed in bone marrow cells. The results showed that all three substances were weak genotoxicants. Tequila showed the strongest response followed by brandy and ethanol. None of them modified the cell proliferation kinetics as demonstrated by the AGT results.",

keywords = "Brandy, Ethanol, Mouse bone marrow, Sister chromatid exchanges, Tequila",

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AU - Calva, A. Piña

AU - Madrigal-Bujaidar, E.

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Y1 - 1993/1

N2 - The genotoxicity of ethanol, tequila and brandy was evaluated by scoring the frequency of sister chromatid exchanges (SCE) and determining the values of the average generation time (AGT). We studied four dosages of each substance i.p. inoculated into mice. The cytogenetic analysis was performed in bone marrow cells. The results showed that all three substances were weak genotoxicants. Tequila showed the strongest response followed by brandy and ethanol. None of them modified the cell proliferation kinetics as demonstrated by the AGT results.

AB - The genotoxicity of ethanol, tequila and brandy was evaluated by scoring the frequency of sister chromatid exchanges (SCE) and determining the values of the average generation time (AGT). We studied four dosages of each substance i.p. inoculated into mice. The cytogenetic analysis was performed in bone marrow cells. The results showed that all three substances were weak genotoxicants. Tequila showed the strongest response followed by brandy and ethanol. None of them modified the cell proliferation kinetics as demonstrated by the AGT results.

KW - Brandy

KW - Ethanol

KW - Mouse bone marrow

KW - Sister chromatid exchanges

KW - Tequila

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DO - 10.1016/0378-4274(93)90072-6

M3 - Artículo

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EP - 5

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1

ER -

SCE frequencies induced by ethanol, tequila and brandy in mouse bone marrow cells in vivo

Abstract

Keywords

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