Papel de los grupos sulfhidrilos, las prostaglandinas y el óxido nítrico endógeno, en la gastroprotección del lanosterol sobre las lesiones gástricas inducidas por etanol en rata

The lanosterol activity was evaluated on gastric mucosal damage induced in rats by ethanol. Lanosterol at 3, 10, 30 and 100 mg/kg showed 26, 33, 51 and 59 % gastroprotection, respectively. The gastroprotection of this compound was attenuated with N-ethylmaleimide (10 mg/kg) suggesting that the gastroprotective mechanism of this compound is due at least in part to the participation of sulfydryl groups. The gastroprotective effect of lanosterol was not affected by N ^G-nitro-L-arginine methyl ester (70 mg/kg) nor indometacin (10 mg/kg), indicating that nitric oxide and prostaglandins seem to have little participation in the mechanism of gastroprotection of lanosterol. Carbenoxolone was used as a gastroprotective model drug and the results obtained in the current study are in agreement with those previously reported.