Risk Factors for Thrombosis Development in Mexican Patients

César Zavala-Hernández, Edgar Hernández-Zamora, Carlos Martínez-Murillo, Abraham Majluf-Cruz, Jorge Vela-Ojeda, Jaime García-Chávez, Elba Reyes-Maldonado

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Abstract

© 2015 Elsevier Inc. Background To identify inherited factors: Protein C (PC), protein S (PS), antithrombin (AT), plasminogen (Plg), the activated PC resistance (APCR), prothrombin (PT) mutation G20210 A (PTG20210 A) and methylenetetrahydrofolate reductase C677 T polymorphism (MTHFR C677 T), as well as acquired-risk factors such as: diabetes mellitus, surgeries, smoking, obesity, hypertension, trauma, alcoholism, family history; and their association, in Mexican patients with diagnostic of thrombophilia. Methods Overall, 200 patients diagnosed with thrombophilia and 100 healthy controls. Commercial kits were used for the coagulometric tests and polymerase chain reaction, restriction fragment length polymorphism for molecular alterations. Results Alterations were found with an estimated prevalence to PC 0.65%, AT 2.04% and Plg 2.5%, APCR 2%, PT 20210 2%, and MTHFR 65%. The C677 T polymorphism of the MTHFR did not associate with acquired-risk factors so we can suppose that it is an independent risk factor. For the patients that only presented acquired-risk factors (21 of 200), the association smoking-alcoholism showed to be the cause of thrombosis with high risk. The following were also associated: smoking with AT, PC, and alcoholism; obesity with Plg; smoking with alcoholism, and PS deficiency. Conclusions Risk factors for both primary and secondary and their association were present as a cause of thrombosis in the patients studied, and the possibility to suffer a recurrent thrombosis.
Original languageAmerican English
Pages (from-to)1625-1632
Number of pages1461
JournalAnnals of Vascular Surgery
DOIs
StatePublished - 1 Jan 2015

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    Zavala-Hernández, C., Hernández-Zamora, E., Martínez-Murillo, C., Majluf-Cruz, A., Vela-Ojeda, J., García-Chávez, J., & Reyes-Maldonado, E. (2015). Risk Factors for Thrombosis Development in Mexican Patients. Annals of Vascular Surgery, 1625-1632. https://doi.org/10.1016/j.avsg.2015.05.035