TY - JOUR
T1 - Rheological mucoadhesion and cytotoxicity of montmorillonite clay mineral/hybrid microparticles biocomposite
AU - García-Guzmán, P.
AU - Medina-Torres, L.
AU - Calderas, F.
AU - Bernad-Bernad, M. J.
AU - Gracia-Mora, J.
AU - Marcos, X.
AU - Correa-Basurto, J.
AU - Núñez-Ramírez, D. M.
AU - Manero, O.
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - A biocomposite based on montmorillonite clay mineral (MMT) and hybrid biopolymer microparticles (MP) carrying atorvastatin (AC), these were designed for oral drug carrier was characterized by scanning and transmission electron microscopy (SEM &TEM), differential scanning calorimetry (DSC) and in vitro biocompatibility by cell viability on fibroblast cells. The rheological synergism relation (by linear oscillatory tests at different pH and frequency) with the mucoadhesive properties revealed interactions between isolated mucin and the MP/MMT biocomposite and those between the mucin and the individual components. Results of these tests showed that the MP/MMT biocomposite provides an improvement in the thermal stability and hence good biocompatibility exhibiting anti-proliferation effects at high concentrations. To our knowledge, no previous reports exist on the determination of the rheological synergism in biocomposites with MMT clay either alone. Moreover, we found a dependence of the rheological synergism on pH and frequency provided by linear viscoelastic data at low frequencies. The MP/MMT biocomposite possesses the highest rheological synergism related to the strongest interaction with mucin at pH 1.6.
AB - A biocomposite based on montmorillonite clay mineral (MMT) and hybrid biopolymer microparticles (MP) carrying atorvastatin (AC), these were designed for oral drug carrier was characterized by scanning and transmission electron microscopy (SEM &TEM), differential scanning calorimetry (DSC) and in vitro biocompatibility by cell viability on fibroblast cells. The rheological synergism relation (by linear oscillatory tests at different pH and frequency) with the mucoadhesive properties revealed interactions between isolated mucin and the MP/MMT biocomposite and those between the mucin and the individual components. Results of these tests showed that the MP/MMT biocomposite provides an improvement in the thermal stability and hence good biocompatibility exhibiting anti-proliferation effects at high concentrations. To our knowledge, no previous reports exist on the determination of the rheological synergism in biocomposites with MMT clay either alone. Moreover, we found a dependence of the rheological synergism on pH and frequency provided by linear viscoelastic data at low frequencies. The MP/MMT biocomposite possesses the highest rheological synergism related to the strongest interaction with mucin at pH 1.6.
KW - Biocomposite
KW - Cytotoxicity
KW - Drug carrier
KW - Hybrid microparticles
KW - Montmorillonite clay mineral
KW - Rheological-mucoadhesion
UR - http://www.scopus.com/inward/record.url?scp=85067846939&partnerID=8YFLogxK
U2 - 10.1016/j.clay.2019.105202
DO - 10.1016/j.clay.2019.105202
M3 - Artículo
AN - SCOPUS:85067846939
SN - 0169-1317
VL - 180
JO - Applied Clay Science
JF - Applied Clay Science
M1 - 105202
ER -