Relationship between Helicobacter pylori and undifferentiated non-granulomatous anterior uveitis

Héctor Javier Pérez-Cano, Jimena Ceja-Martínez, Vanessa Tellezgiron-Lara, Stephanie Voorduin-Ramos, Oscar Morales-López, Selma Alin Somilleda-Ventura

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The relationship of Helicobacter pylori infection with ocular diseases, including anterior uveitis, has been reported. The objective of this study was to determine the presence of anti-H. pylori IgG antibodies in patients with idiopathic non-granulomatous anterior uveitis and compare the results with a control group. Methods: A prospective, comparative, and cross-sectional study was conducted. Patients with idiopathic granulomatous anterior uveitis and a group of control subjects were included. The presence of anti-H. pylori IgG antibodies was determined. The chi-square test was performed for comparative analysis with GraphPad Prism V5.0 software. Results: Thirty patients with idiopathic non-granulomatous anterior uveitis and 35 control subjects were included. In the determination of anti-H. pylori IgG antibodies, 24 (80%) patients and 19 (54%) control subjects were positive. A significant difference (p = 0.0263) was found between the groups and an odds ratio (OR) of 3.37. Conclusions: A direct relationship was found between the presence of anti-H. pylori IgG antibodies and idiopathic non-granulomatous anterior uveitis. An association can be established between idiopathic non-granulomatous anterior uveitis and H. pylori infection, without this being a causal or physiopathogenic relationship.

Original languageEnglish
Pages (from-to)765-768
Number of pages4
JournalInfection
Volume51
Issue number3
DOIs
StatePublished - Jun 2023
Externally publishedYes

Keywords

  • Anterior uveitis
  • Helicobacter pylori
  • Ocular diseases

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