Regulation of intestinal morphology and GALT by pituitary hormones in the rat

Luz María Cárdenas-Jaramillo, Andrés Quintanar-Stephano, Rosa Adriana Jarillo-Luna, Víctor Rivera-Aguilar, Gabriela Oliver-Aguillón, Rafael Campos-Rodríguez, Kalman Kovacs, Istvan Berczi

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    Abstract

    Here, the effects of neurointermediate (NIL), anterior (AL), and total hypophysectomy (HYPOX) on ileal mucosa cells and gut-associated lymphoid tissue (GALT) are reported. Compared with the sham-operated (SHAM) rats, the villi height and goblet cells numbers were significantly decreased in all groups. Lamina propria area decreased in AL and HYPOX, but not in NIL animals. CD8+ but not CD4+ lymphocytes decreased in the HYPOX and NIL groups. Paneth cells did not change, while IgA cells, IgM cells, and secretory IgA were significantly decreased in all groups. NIL but not AL animals lost significant numbers of IgA cells and secretory IgA. In summary, pituitary hormones exert lobe-specific regulatory effects on the gut and on GALT.

    Original languageEnglish
    Pages (from-to)72-78
    Number of pages7
    JournalAnnals of the New York Academy of Sciences
    Volume1261
    Issue number1
    DOIs
    StatePublished - Jul 2012

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    Keywords

    • Anterior and neurointermediate pituitary lobectomy
    • Gut associated lymphoid tissue
    • Gut morphology
    • Hypophysectomy
    • Pituitary hormones

    Cite this

    Cárdenas-Jaramillo, L. M., Quintanar-Stephano, A., Jarillo-Luna, R. A., Rivera-Aguilar, V., Oliver-Aguillón, G., Campos-Rodríguez, R., Kovacs, K., & Berczi, I. (2012). Regulation of intestinal morphology and GALT by pituitary hormones in the rat. Annals of the New York Academy of Sciences, 1261(1), 72-78. https://doi.org/10.1111/j.1749-6632.2012.06648.x