TY - JOUR
T1 - Recent advances in the development of methyltransferase (MTase) inhibitors against (re)emerging arboviruses diseases dengue and Zika
AU - Delgado-Maldonado, Timoteo
AU - Moreno-Herrera, Antonio
AU - Pujadas, Gerard
AU - Vázquez-Jiménez, Lenci K.
AU - González-González, Alonzo
AU - Rivera, Gildardo
N1 - Publisher Copyright:
© 2023 Elsevier Masson SAS
PY - 2023/4/5
Y1 - 2023/4/5
N2 - Emerging and/or re-emerging viral diseases such as dengue and Zika are a worldwide concern. Therefore, new antiviral therapeutics are necessary. In this sense, a non-structural protein with methyltransferase (MTase) activity is an attractive drug target because it plays a crucial role in dengue and Zika virus replication. Different drug strategies such as virtual screening, molecular docking, and molecular dynamics have identified new inhibitors that bind on the MTase active site. Therefore, in this review, we analyze MTase inhibitors, including S-adenosyl-L-methionine (SAM), S-adenosyl-L-homocysteine (SAH) and guanosine-5′-triphosphate (GTP) analogs, nitrogen-containing heterocycles (pyrimidine, adenosine, and pyridine), urea derivatives, and natural products. Advances in the design of MTase inhibitors could lead to the optimization of a possible single or broad-spectrum antiviral drug against dengue and Zika virus.
AB - Emerging and/or re-emerging viral diseases such as dengue and Zika are a worldwide concern. Therefore, new antiviral therapeutics are necessary. In this sense, a non-structural protein with methyltransferase (MTase) activity is an attractive drug target because it plays a crucial role in dengue and Zika virus replication. Different drug strategies such as virtual screening, molecular docking, and molecular dynamics have identified new inhibitors that bind on the MTase active site. Therefore, in this review, we analyze MTase inhibitors, including S-adenosyl-L-methionine (SAM), S-adenosyl-L-homocysteine (SAH) and guanosine-5′-triphosphate (GTP) analogs, nitrogen-containing heterocycles (pyrimidine, adenosine, and pyridine), urea derivatives, and natural products. Advances in the design of MTase inhibitors could lead to the optimization of a possible single or broad-spectrum antiviral drug against dengue and Zika virus.
KW - Dengue
KW - Drug treatment
KW - Inhibitors
KW - Methyltransferase
KW - Mosquito-borne viruses
KW - Re-emerging viral diseases
KW - Zika
UR - http://www.scopus.com/inward/record.url?scp=85150382122&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2023.115290
DO - 10.1016/j.ejmech.2023.115290
M3 - Artículo de revisión
C2 - 36958266
AN - SCOPUS:85150382122
SN - 0223-5234
VL - 252
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
M1 - 115290
ER -