TY - JOUR
T1 - Recent advances in the development of broad-spectrum antiprotozoal agents
AU - Moreno-Herrera, Antonio
AU - Cortez-Maya, Sandra
AU - Bocanegra-Garcia, Virgilio
AU - Banik, Bimal Krishna
AU - Rivera, Gildardo
N1 - Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Enta-moeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are part of a large list of human parasitic diseases. Together, they cause more than 500 million infections per year. These protozoa parasites affect both low-and high-income countries and their pharmacological treatments are limited. Therefore, new and more effective drugs in preclinical development could improve overall therapy for parasitic infections even when their mechanisms of action are unknown. In this review, a number of heterocyclic compounds (diamidine, guanidine, quinoline, benzimidaz-ole, thiazole, diazanaphthalene, and their derivatives) reported as antiprotozoal agents are discussed as options for developing new pharmacological treatments for parasitic diseases.
AB - Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Enta-moeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are part of a large list of human parasitic diseases. Together, they cause more than 500 million infections per year. These protozoa parasites affect both low-and high-income countries and their pharmacological treatments are limited. Therefore, new and more effective drugs in preclinical development could improve overall therapy for parasitic infections even when their mechanisms of action are unknown. In this review, a number of heterocyclic compounds (diamidine, guanidine, quinoline, benzimidaz-ole, thiazole, diazanaphthalene, and their derivatives) reported as antiprotozoal agents are discussed as options for developing new pharmacological treatments for parasitic diseases.
KW - Antiprotozoal
KW - Drugs
KW - Entamoeba histolytica
KW - Giardia lamblia
KW - Leishmania spp
KW - Plasmodium spp
KW - Trichomonas vaginalis
KW - Trypanosoma brucei
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=85091146311&partnerID=8YFLogxK
U2 - 10.2174/0929867327666200303170000
DO - 10.2174/0929867327666200303170000
M3 - Artículo de revisión
C2 - 32124688
AN - SCOPUS:85091146311
SN - 0929-8673
VL - 28
SP - 583
EP - 606
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 3
ER -