Participación de las especies reactivas del oxígeno en las enfermedades pulmonares

Translated title of the contribution: Reactive Oxygen Species (ROS) participation in pulmonary diseases

Martha Patricia Sierra Vargas, Alberto Martín Guzmán-Grenfell, Ivonne María Olivares-Corichi, Yessica Dorin Torres Ramos, Juan José Hicks Gómez

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Reactive Oxygen Species (ROS) are very reactive molecules (O 2 •-, HO , NO ) since they have a single and unpaired electron in the last orbital (free radical) which confers them physical instability. Free radical precursors such as H 2O 2, HONO 2 - are considered ROS. These species are important in the physiological processes. When ROS production exceeds the inactivation mechanisms, oxidative stress takes place. This stress is characterized by molecular and cellular damage which predisposes to or modifies chronic-degenerative diseases. Among pulmonary diseases in which ROS participation has been proved are ARDS, COPD and asthma. The aim of this paper was to analyze the mechanisms of oxidative stress that lead to those illnesses.

Translated title of the contributionReactive Oxygen Species (ROS) participation in pulmonary diseases
Original languageSpanish
Pages (from-to)135-148
Number of pages14
JournalRevista del Instituto Nacional de Enfermedades Respiratorias
Volume17
Issue number2
StatePublished - Apr 2004
Externally publishedYes

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