TY - JOUR
T1 - Participación de las especies reactivas del oxígeno en las enfermedades pulmonares
AU - Vargas, Martha Patricia Sierra
AU - Guzmán-Grenfell, Alberto Martín
AU - Olivares-Corichi, Ivonne María
AU - Ramos, Yessica Dorin Torres
AU - Gómez, Juan José Hicks
PY - 2004/4
Y1 - 2004/4
N2 - Reactive Oxygen Species (ROS) are very reactive molecules (O 2 •-, HO •, NO •) since they have a single and unpaired electron in the last orbital (free radical) which confers them physical instability. Free radical precursors such as H 2O 2, HONO 2 - are considered ROS. These species are important in the physiological processes. When ROS production exceeds the inactivation mechanisms, oxidative stress takes place. This stress is characterized by molecular and cellular damage which predisposes to or modifies chronic-degenerative diseases. Among pulmonary diseases in which ROS participation has been proved are ARDS, COPD and asthma. The aim of this paper was to analyze the mechanisms of oxidative stress that lead to those illnesses.
AB - Reactive Oxygen Species (ROS) are very reactive molecules (O 2 •-, HO •, NO •) since they have a single and unpaired electron in the last orbital (free radical) which confers them physical instability. Free radical precursors such as H 2O 2, HONO 2 - are considered ROS. These species are important in the physiological processes. When ROS production exceeds the inactivation mechanisms, oxidative stress takes place. This stress is characterized by molecular and cellular damage which predisposes to or modifies chronic-degenerative diseases. Among pulmonary diseases in which ROS participation has been proved are ARDS, COPD and asthma. The aim of this paper was to analyze the mechanisms of oxidative stress that lead to those illnesses.
KW - Diseases
KW - Free radicals
KW - Lung
KW - Oxidative injuries
KW - Oxidative stress
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=4644350160&partnerID=8YFLogxK
M3 - Artículo de revisión
SN - 0187-7585
VL - 17
SP - 135
EP - 148
JO - Revista del Instituto Nacional de Enfermedades Respiratorias
JF - Revista del Instituto Nacional de Enfermedades Respiratorias
IS - 2
ER -