Raman spectrum modification of CdSe/ZnS quantum dots at the bio-conjugation to IgG antibodies

A. I. Diaz Cano, J. Douda, C. R. Gonzalez Vargas, K. Gazarian

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

The paper presents the analysis of Raman scattering spectra of non-conjugated and bio-conjugated CdSe/ZnS core-shell quantum dots in the range of Raman shifts of 80-2000 cm -1. Commercial CdSe/ZnS QDs covered by polymer and characterized by color emission with the maxima at 605 and 655 nm (1.89 and 2.04 eV) were used. Raman scattering spectra were measured at 300K and the excitation by the line 785.0 nm of a solid state LED. The analysis of Raman spectra has shown that the QD bio-conjugation to the immunoglobulin G (IgG) antibodies of the Pseudorabies virus is accompanied by the changes of the intensity of Raman lines related to the CdSe/ZnS core/shell QDs, PEG polymer covered QDs, the Si substrate and/or some organic groups of antibody molecules. The comparison of Raman spectra of CdSe/ZnS QDs with different sizes in non-conjugated and bio-conjugated states gives the opportunity to detect the bio-conjugation without mistake.

Original languageEnglish
Title of host publicationNanostructured Materials and Nanotechnology
Pages45-50
Number of pages6
DOIs
StatePublished - 2012
Event20th International Materials Research Congress, IMRC 2011 - Cancun, Mexico
Duration: 14 Aug 201119 Aug 2011

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1371
ISSN (Print)0272-9172

Conference

Conference20th International Materials Research Congress, IMRC 2011
Country/TerritoryMexico
CityCancun
Period14/08/1119/08/11

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