Pyrrolizidine Alkaloids

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    6 Scopus citations

    Abstract

    Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources. The interest of the scientific community in these compounds owes itself to their high toxicity and biological activity, as well as to the challenge of synthesizing their pyrrolizidine scaffold. This review encompasses a wide range of topics found in the literature from 1995 to date, including the occurrence, biosynthesis, toxicity (hepatotoxicity, genotoxicity, and tumorigenicity), biological activity, and pharmacological properties (glycosidase inhibitory activity) of these secondary metabolites. Particular attention is given to the chemistry of PAs, addressing general strategies for formal and total syntheses via amino-based substrates, pyrroles, and pyrrolidine-based derivatives.

    Original languageEnglish
    Title of host publicationAlkaloids
    Subtitle of host publicationChemistry and Biology
    EditorsHans-Joachim Knölker
    PublisherAcademic Press Inc.
    Pages1-314
    Number of pages314
    ISBN (Print)9780128157909
    DOIs
    StatePublished - 1 Jan 2018

    Publication series

    NameAlkaloids: Chemistry and Biology
    Volume80
    ISSN (Print)1099-4831

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    Keywords

    • Biosynthesis
    • Glycosidase inhibition
    • Hepatotoxicity
    • Natural occurrence
    • Necine bases
    • Pyrrolizidine alkaloids
    • Pyrrolizidine synthesis

    Cite this

    Tamariz, J., Burgueño-Tapia, E., Vázquez, M. A., & Delgado, F. (2018). Pyrrolizidine Alkaloids. In H-J. Knölker (Ed.), Alkaloids: Chemistry and Biology (pp. 1-314). (Alkaloids: Chemistry and Biology; Vol. 80). Academic Press Inc.. https://doi.org/10.1016/bs.alkal.2018.03.001