TY - JOUR
T1 - PVA-Based Electrospun Biomembranes with Hydrolyzed Collagen and Ethanolic Extract of Hypericum perforatum for Potential Use as Wound Dressing
T2 - Fabrication and Characterization
AU - García-Hernández, Alitzel Belém
AU - Morales-Sánchez, Eduardo
AU - Berdeja-Martínez, Blanca M.
AU - Escamilla-García, Monserrat
AU - Salgado-Cruz, Ma Paz
AU - Rentería-Ortega, Minerva
AU - Farrera-Rebollo, Reynold R.
AU - Vega-Cuellar, Miguel A.
AU - Calderón-Domínguez, Georgina
N1 - Publisher Copyright:
© 2022 by the author. Licensee MDPI, Basel, Switzerland.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Biological, physicochemical, structural, and thermal properties of PVA-based electrospun wound dressings added with hydrolyzed collagen (HC) and different concentrations of Hypericum perforatum ethanolic extract (EEHP) were studied. Membrane characterization was carried out by Xray diffraction, Fourier infrared spectroscopy, differential scanning calorimetry, barrier properties, scanning electron microscopy, image analysis (diameter and pore size), as well as antimicrobial and anti-inflammatory activities. Results showed that the PVA/HC/EEHP materials, fabricated under controlled conditions of temperature and humidity, generated fiber membranes with diameters between 140–390 nm, adequate porosity and pore size for cell growth (67–90% and 4–16 µm, respectively), and good barrier properties (0.005–0.032 gm−2 s−1) to be used in the treatment of conditions on the skin, and was even better than some commercial products. Finally, they showed to have anti-inflammatory (>80%), and antimicrobial activity against S. aureus and S. Epiderm. Furthermore, higher crystalline structure was observed according to the EEHP concentration. In addition, this is the first report in which PVA/HC/EEHP membranes are successfully fabricated and characterized.
AB - Biological, physicochemical, structural, and thermal properties of PVA-based electrospun wound dressings added with hydrolyzed collagen (HC) and different concentrations of Hypericum perforatum ethanolic extract (EEHP) were studied. Membrane characterization was carried out by Xray diffraction, Fourier infrared spectroscopy, differential scanning calorimetry, barrier properties, scanning electron microscopy, image analysis (diameter and pore size), as well as antimicrobial and anti-inflammatory activities. Results showed that the PVA/HC/EEHP materials, fabricated under controlled conditions of temperature and humidity, generated fiber membranes with diameters between 140–390 nm, adequate porosity and pore size for cell growth (67–90% and 4–16 µm, respectively), and good barrier properties (0.005–0.032 gm−2 s−1) to be used in the treatment of conditions on the skin, and was even better than some commercial products. Finally, they showed to have anti-inflammatory (>80%), and antimicrobial activity against S. aureus and S. Epiderm. Furthermore, higher crystalline structure was observed according to the EEHP concentration. In addition, this is the first report in which PVA/HC/EEHP membranes are successfully fabricated and characterized.
KW - Electrospinning
KW - Hydrolyzed collagen
KW - Hypericum perforatum
KW - Polyvinyl alcohol
KW - Wound dressing
UR - http://www.scopus.com/inward/record.url?scp=85132547989&partnerID=8YFLogxK
U2 - 10.3390/polym14101981
DO - 10.3390/polym14101981
M3 - Artículo
C2 - 35631864
AN - SCOPUS:85132547989
SN - 2073-4360
VL - 14
JO - Polymers
JF - Polymers
IS - 10
M1 - 1981
ER -