Production of free radicals derived from oxygen and hepatocyte damage

José Gutiérrez Salinas, José Antonio Morales González

Research output: Contribution to journalScientific reviewResearchpeer-review

6 Citations (Scopus)

Abstract

Free radical is an atom or molecule that contains an unpaired electron at external orbital. Free radicals derived from oxygen are most important. These later are regularly produced in the cell as a result of the metabolic pathways activity. A variety of anti-oxidant defense are in the cell, the most important are the enzymatic defense. The most important anti-oxidant defense are catalase, superoxyde dismutase and glutathione system. It is showed that a xenobiotic administration produces an increase in free radicals production, a decrease in anti-oxidant defense, or both. Free radicals produced by xenobiotic intoxication are related to several pathological manifestation of disease. Some body organs such as brain, kidney and liver are important free radicals producers. The liver is an important source of investigation due to free radicals production is a pathological manifestation of disease.
Original languageAmerican English
Pages (from-to)287-295
Number of pages257
JournalMedicina Interna de Mexico
StatePublished - 1 Jul 2004
Externally publishedYes

Fingerprint

Free radicals
free radicals
Free Radicals
Hepatocytes
Oxygen
damage
oxygen
Oxidants
Xenobiotics
liver
Liver
intoxication
catalase
glutathione
kidneys
Metabolic Networks and Pathways
cells
organs
Catalase
brain

Cite this

@article{b72db82605c348b7bb93aec643f595e3,
title = "Production of free radicals derived from oxygen and hepatocyte damage",
abstract = "Free radical is an atom or molecule that contains an unpaired electron at external orbital. Free radicals derived from oxygen are most important. These later are regularly produced in the cell as a result of the metabolic pathways activity. A variety of anti-oxidant defense are in the cell, the most important are the enzymatic defense. The most important anti-oxidant defense are catalase, superoxyde dismutase and glutathione system. It is showed that a xenobiotic administration produces an increase in free radicals production, a decrease in anti-oxidant defense, or both. Free radicals produced by xenobiotic intoxication are related to several pathological manifestation of disease. Some body organs such as brain, kidney and liver are important free radicals producers. The liver is an important source of investigation due to free radicals production is a pathological manifestation of disease.",
author = "Salinas, {Jos{\'e} Guti{\'e}rrez} and Gonz{\'a}lez, {Jos{\'e} Antonio Morales}",
year = "2004",
month = "7",
day = "1",
language = "American English",
pages = "287--295",
journal = "Medicina Interna de Mexico",
issn = "0186-4866",
publisher = "Comunicaciones Cientificas Mexicanas S.A. de C.V.",

}

Production of free radicals derived from oxygen and hepatocyte damage. / Salinas, José Gutiérrez; González, José Antonio Morales.

In: Medicina Interna de Mexico, 01.07.2004, p. 287-295.

Research output: Contribution to journalScientific reviewResearchpeer-review

TY - JOUR

T1 - Production of free radicals derived from oxygen and hepatocyte damage

AU - Salinas, José Gutiérrez

AU - González, José Antonio Morales

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Free radical is an atom or molecule that contains an unpaired electron at external orbital. Free radicals derived from oxygen are most important. These later are regularly produced in the cell as a result of the metabolic pathways activity. A variety of anti-oxidant defense are in the cell, the most important are the enzymatic defense. The most important anti-oxidant defense are catalase, superoxyde dismutase and glutathione system. It is showed that a xenobiotic administration produces an increase in free radicals production, a decrease in anti-oxidant defense, or both. Free radicals produced by xenobiotic intoxication are related to several pathological manifestation of disease. Some body organs such as brain, kidney and liver are important free radicals producers. The liver is an important source of investigation due to free radicals production is a pathological manifestation of disease.

AB - Free radical is an atom or molecule that contains an unpaired electron at external orbital. Free radicals derived from oxygen are most important. These later are regularly produced in the cell as a result of the metabolic pathways activity. A variety of anti-oxidant defense are in the cell, the most important are the enzymatic defense. The most important anti-oxidant defense are catalase, superoxyde dismutase and glutathione system. It is showed that a xenobiotic administration produces an increase in free radicals production, a decrease in anti-oxidant defense, or both. Free radicals produced by xenobiotic intoxication are related to several pathological manifestation of disease. Some body organs such as brain, kidney and liver are important free radicals producers. The liver is an important source of investigation due to free radicals production is a pathological manifestation of disease.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33749649961&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33749649961&origin=inward

M3 - Scientific review

SP - 287

EP - 295

JO - Medicina Interna de Mexico

JF - Medicina Interna de Mexico

SN - 0186-4866

ER -