Preparation of apoptotic inducers, 2,2-diphenyl-1,3,2-oxazaborolidin-5- ones, under alkaline conditions

Benjamín Velasco-Bejarano, José Trujillo-Ferrara, René Miranda

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

An efficient and high-yielding procedure has been developed for the synthesis of a set of fifteen 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones, through the reaction of the corresponding examino acid with diphenyl borinic acid under alkaline conditions (pH 7.5-8). It is of note that these compounds showed potent cytotoxic activity on K-562 and HCT-15 cell lines. © Georg Thieme Verlag Stuttgart.
Original languageAmerican English
Pages (from-to)921-924
Number of pages828
JournalSynlett
DOIs
StatePublished - 3 Apr 2007

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Cells
preparation
acids
Acids
cultured cells
synthesis
diphenyl
diphenylborinic acid

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abstract = "An efficient and high-yielding procedure has been developed for the synthesis of a set of fifteen 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones, through the reaction of the corresponding examino acid with diphenyl borinic acid under alkaline conditions (pH 7.5-8). It is of note that these compounds showed potent cytotoxic activity on K-562 and HCT-15 cell lines. {\circledC} Georg Thieme Verlag Stuttgart.",
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Preparation of apoptotic inducers, 2,2-diphenyl-1,3,2-oxazaborolidin-5- ones, under alkaline conditions. / Velasco-Bejarano, Benjamín; Trujillo-Ferrara, José; Miranda, René.

In: Synlett, 03.04.2007, p. 921-924.

Research output: Contribution to journalArticleResearchpeer-review

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