TY - JOUR
T1 - Preparation of apoptotic inducers, 2,2-diphenyl-1,3,2-oxazaborolidin-5- ones, under alkaline conditions
AU - Velasco-Bejarano, Benjamín
AU - Trujillo-Ferrara, José
AU - Miranda, René
PY - 2007/4/3
Y1 - 2007/4/3
N2 - An efficient and high-yielding procedure has been developed for the synthesis of a set of fifteen 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones, through the reaction of the corresponding examino acid with diphenyl borinic acid under alkaline conditions (pH 7.5-8). It is of note that these compounds showed potent cytotoxic activity on K-562 and HCT-15 cell lines.
AB - An efficient and high-yielding procedure has been developed for the synthesis of a set of fifteen 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones, through the reaction of the corresponding examino acid with diphenyl borinic acid under alkaline conditions (pH 7.5-8). It is of note that these compounds showed potent cytotoxic activity on K-562 and HCT-15 cell lines.
KW - Apoptosis
KW - Boron complexes
KW - Diphenylborinic acid
KW - Diphenyloxazaborolidinones
KW - α-amino acids
UR - http://www.scopus.com/inward/record.url?scp=34247169495&partnerID=8YFLogxK
U2 - 10.1055/s-2007-973886
DO - 10.1055/s-2007-973886
M3 - Artículo
SN - 0936-5214
SP - 921
EP - 924
JO - Synlett
JF - Synlett
IS - 6
ER -