TY - JOUR
T1 - Preclinical antitoxic properties of Spirulina (Arthrospira)
AU - Martínez-Galero, Elizdath
AU - Pérez-Pastén, Ricardo
AU - Perez-Juarez, Angélica
AU - Fabila-Castillo, Luis
AU - Gutiérrez-Salmeán, Gabriela
AU - Chamorro, German
N1 - Publisher Copyright:
© 2015 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2016/8/2
Y1 - 2016/8/2
N2 - Abstract: Context: Spirulina (Arthrospira) exerts a wide spectrum of pharmacological activities which are mainly attributed to its antioxidant effect. However, Spirulina has also been reported (both in preclinical and in clinical scenarios) to exhibit other bioactive effects, including an antitoxic potential. Objective: We performed a systematic review of the literature, conducted in TOXNET, PubMed/MEDLINE, and Science Direct-Scopus; all available years were included. Searching criteria included the effects of Spirulina on experimental poisonings from arsenic, cadmium, carbon tetrachloride, deltamethrin, fluoride, hexachlorocyclohexane, iron, lead, lindane, and mercury. Results: In all cases, it was established that the blue-green alga, and its isolated compounds, effectively counteracted these pollutants toxic effects on the exposed organisms. Some molecular mechanisms are proposed, although they have not been fully elucidated yet. Conclusion: Spirulina could be a useful coadjuvant agent within clinical practice for treatment of these or other pollutants poisonings.
AB - Abstract: Context: Spirulina (Arthrospira) exerts a wide spectrum of pharmacological activities which are mainly attributed to its antioxidant effect. However, Spirulina has also been reported (both in preclinical and in clinical scenarios) to exhibit other bioactive effects, including an antitoxic potential. Objective: We performed a systematic review of the literature, conducted in TOXNET, PubMed/MEDLINE, and Science Direct-Scopus; all available years were included. Searching criteria included the effects of Spirulina on experimental poisonings from arsenic, cadmium, carbon tetrachloride, deltamethrin, fluoride, hexachlorocyclohexane, iron, lead, lindane, and mercury. Results: In all cases, it was established that the blue-green alga, and its isolated compounds, effectively counteracted these pollutants toxic effects on the exposed organisms. Some molecular mechanisms are proposed, although they have not been fully elucidated yet. Conclusion: Spirulina could be a useful coadjuvant agent within clinical practice for treatment of these or other pollutants poisonings.
KW - Antidotes
KW - environmental pollutants
KW - occupational pollutants
KW - poisoning
KW - therapy
KW - toxicity
UR - http://www.scopus.com/inward/record.url?scp=84945205536&partnerID=8YFLogxK
U2 - 10.3109/13880209.2015.1077464
DO - 10.3109/13880209.2015.1077464
M3 - Artículo de revisión
C2 - 26439611
SN - 1388-0209
VL - 54
SP - 1345
EP - 1353
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 8
ER -