PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity

Patricia Canto, Jesús Benítez Granados, Guillermo Feria-Bernal, Ramón Mauricio Coral-Vázquez, Eduardo García-García, María Elena Tejeda, André Tapia, David Rojano-Mejía, Juan Pablo Méndez

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

© 2017 IOS Press and the authors. All rights reserved. BACKGROUND: Obesity constitutes a risk factor for the development of aggressive forms of prostate cancer. It has been proposed, that prostate cancer has a genetic predisposition and that PPARGC1A and ADIPOQ polymorphisms play a role in the development of this condition. OBJECTIVE: To analyse the association of two PPARGC1A and ADIPOQ polymorphisms as well as their haplotypes, with the development of aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity. SUBJECTS AND METHODS: Two hundred fifty seven men with prostate cancer of Mexican-Mestizo origin were included. Body mass index (BMI) was determined and the degree of prostate cancer aggressiveness by the D'Amico classification. DNA was obtained. Rs7665116 and rs2970870 of PPARGC1A, and rs266729 and rs1501299 of ADIPOQ were studied by real-time PCR allelic discrimination. Pairwise linkage disequilibrium, between single nucleotide polymorphisms was calculated and haplotype analysis was performed. RESULTS: A higher-risk (D'Amico classification) was observed in 21.8% of patients. An association of cancer aggressiveness with rs2970870 of PPARGC1A, and rs501299 of ADIPOQ, as well as with one haplotype of ADIPOQ was documented. CONCLUSIONS: This is the first study regarding the relationship of PPARGC1A and ADIPOQ polymorphisms, and the aggressiveness of prostate cancer in men with overweight or obesity.
Original languageAmerican English
Pages (from-to)297-303
Number of pages266
JournalCancer Biomarkers
DOIs
StatePublished - 1 Jan 2017

Fingerprint Dive into the research topics of 'PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity'. Together they form a unique fingerprint.

  • Cite this

    Canto, P., Granados, J. B., Feria-Bernal, G., Coral-Vázquez, R. M., García-García, E., Tejeda, M. E., Tapia, A., Rojano-Mejía, D., & Méndez, J. P. (2017). PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity. Cancer Biomarkers, 297-303. https://doi.org/10.3233/CBM-160467