TY - JOUR
T1 - Posible asociación entre preeclampsia-eclampsia y la edad paterna
T2 - Estudio piloto
AU - García-Ortiz, Liliana
AU - Gutiérrez-Salinas, José
AU - Galaviz-Hernández, Carlos
AU - Chima-Galán, María del Carmen
AU - Hilton-Cáceres, José M.
AU - Escobedo-Aguirre, Fernando
AU - de la Peña-Gutiérrez, Marlene
AU - Iniesta-Mejía, Antonio
AU - Miranda-Murillo, Juan
PY - 2011/4
Y1 - 2011/4
N2 - Background: The preeclampsia is a multisystemic syndrome that occupied the first cause of maternal and fetal mortality around the world. Epidemiologic studies shown both mother and father contribute at the same risk for preeclampsia. Objective: To determinate if there is an association between preeclampsia and paternal age. Material and method: Preeclampsia-eclampsia patients and couples were analyzed in agree to "National High Blood Pressure Education Program Working Group" classification, and a control group constituted by normal pregnant women and couples was included. Results: There were 27 cases with mild preeclampsia and her couples, 13 cases with severe preeclampsia and her couples and 40 controls conformed by normal pregnant women and her couples. The statistical analysis of variance of the ages shown that men from preeclamptic group had a greater variance in contrast with man of control group (p < 0.001; valor of F = 5.084). Conclusions: Although is not clear how paternal age interview in preeclampsia risk, the interaction between paternal-maternal imprinting and spermatic senescence, followed by shortened telomeres of chromosome, could be produce the inactivity of a whole network of signals implicated in disease aetiology.
AB - Background: The preeclampsia is a multisystemic syndrome that occupied the first cause of maternal and fetal mortality around the world. Epidemiologic studies shown both mother and father contribute at the same risk for preeclampsia. Objective: To determinate if there is an association between preeclampsia and paternal age. Material and method: Preeclampsia-eclampsia patients and couples were analyzed in agree to "National High Blood Pressure Education Program Working Group" classification, and a control group constituted by normal pregnant women and couples was included. Results: There were 27 cases with mild preeclampsia and her couples, 13 cases with severe preeclampsia and her couples and 40 controls conformed by normal pregnant women and her couples. The statistical analysis of variance of the ages shown that men from preeclamptic group had a greater variance in contrast with man of control group (p < 0.001; valor of F = 5.084). Conclusions: Although is not clear how paternal age interview in preeclampsia risk, the interaction between paternal-maternal imprinting and spermatic senescence, followed by shortened telomeres of chromosome, could be produce the inactivity of a whole network of signals implicated in disease aetiology.
KW - Eclampsia
KW - Imprinting
KW - Paternal age
KW - Preeclampsia
KW - Trophoblastic invasion
UR - http://www.scopus.com/inward/record.url?scp=79957555863&partnerID=8YFLogxK
M3 - Artículo
SN - 0300-9041
VL - 79
SP - 190
EP - 196
JO - Ginecologia y Obstetricia de Mexico
JF - Ginecologia y Obstetricia de Mexico
IS - 4
ER -