Platelet-rich plasma peptides: Key for regeneration

Dolores Javier Sánchez-González, Enrique Méndez-Bolaina, Nayeli Isabel Trejo-Bahena

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations


Platelet-derived Growth Factors (GFs) are biologically active peptides that enhance tissue repair mechanisms such as angiogenesis, extracellular matrix remodeling, and cellular effects as stem cells recruitment, chemotaxis, cell proliferation, and differentiation. Platelet-rich plasma (PRP) is used in a variety of clinical applications, based on the premise that higher GF content should promote better healing. Platelet derivatives represent a promising therapeutic modality, offering opportunities for treatment of wounds, ulcers, soft-tissue injuries, and various other applications in cell therapy. PRP can be combined with cell-based therapies such as adipose-derived stem cells, regenerative cell therapy, and transfer factors therapy. This paper describes the biological background of the platelet-derived substances and their potential use in regenerative medicine.

Original languageEnglish
Article number532519
JournalInternational Journal of Peptides
StatePublished - 2012
Externally publishedYes


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