Abstract
Serotonin administration to pregnant mice and rabbits produces a high incidence of fetal deaths. The number of products that survive, after 5-HT administration, depends upon the gestational age. It was considered interesting to determine the placental levels of 5-HT and 5-HIAA at two different gestational ages. 5-HT average value was 177.9 ± 110.6 ng/g on the 12th day of gestation and 86.0 ± 47.6 ng/g on the 21st (p <0.001). 5-HIAA was 450.3 ± 172.1 ng/g on the 12th day and 131.3 ± 48.4 on the 21st (p < 0.001). The 5-HIAA/5-HT ratio was 3.47 ± 3.64 on the 12th day and 1.76 ± 1.09 on the 21st (p < 0.01). This diminution in the ratio seems to reflect a lowering in the amount or activity of monoamine oxidase. The impairment in the conversion of 5-HT in 5-HIAA at the end of pregnancy could explain the deleterious effect of 5-HT upon the rat fetus in the second half of gestation.
| Translated title of the contribution | Placental indoles in rats with different gestational ages |
|---|---|
| Original language | Spanish |
| Pages (from-to) | 41-45 |
| Number of pages | 5 |
| Journal | Ginecologia y Obstetricia de Mexico |
| Volume | 43 |
| Issue number | 255 |
| State | Published - 1978 |