Piper auritum Kunth (Piperaceae) improves the sexual performance of sluggish male rats through enhancing ejaculation

Rosa Estrada-Reyes, Ana María Dorantes-Barrón, Daniel Arrieta-Báez, Mayra Beatriz Gómez-Patiño, Andrea Bernal-Trujillo, Mario Castro-García, Miguel Carro-Juárez, Lucía Martínez-Mota

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Abstract

© 2018 Elsevier B.V. Ethnopharmacological relevance: Piper auritum Kunth is employed as an aphrodisiac in the traditional medicine, but corroborative evidence for such effect is scarce. Aim of the study: The pro-sexual effect of an aqueous extract of P. auritum and its possible mechanisms were analyzed in two paradigms of male sexual function. Material and methods: Effects of an aqueous extract of P. auritum (PA, single administration) were investigated in the fictive ejaculation, and copulatory behavior paradigms in sexually sluggish male rats. WAY 100635 (antagonist of 5-HT1A receptors), atosiban (antagonist of oxytocinergic receptors), L-NAME (inhibitor of the nitric oxide synthase) and baclofen (antagonist of GABAB receptors) were used as pre-treatments in order to investigate the role of different neurotransmitter systems in PA actions. Chemical profile of PA was determined by Gases Chromatography and Ultra Performance Chromatography-Electrospray Ionization-Masses Spectrometry (UPLC-ESI-MS). Results: In males with retarded ejaculation, PA stimulated ejaculatory behavior and recovered electromyographic activity of pelvic musculature participating in seminal emission and ejaculation. All pre-treatments blocked stimulating effects of PA on the fictive ejaculation; additionally WAY 100635 interfered with PA actions on ejaculatory behavior. Safrol, apigenin dimethylether, myristicin, vaccihein A, sakuranin and sakuranetin flavonoids, were main constituents of PA, with possible participation in its pro-sexual effects. Conclusions: Pro-sexual effects of P. auritum elicited at level of ejaculation were mediated by several neurotransmitter systems, among which serotonin and its 5-HT1A receptors play an important role. Present findings support P. auritum reputation as an aphrodisiac, with potential use in delayed ejaculation disorder.
Original languageAmerican English
Pages (from-to)453-463
Number of pages406
JournalJournal of Ethnopharmacology
DOIs
StatePublished - 1 Mar 2019

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Piperaceae
Piper
Ejaculation
Aphrodisiacs
Receptor, Serotonin, 5-HT1A
Neurotransmitter Agents
Safrole
Baclofen
Electrospray Ionization Mass Spectrometry
NG-Nitroarginine Methyl Ester
Traditional Medicine
Flavonoids
Nitric Oxide Synthase
Gas Chromatography
Chromatography
Therapeutics

Cite this

Estrada-Reyes, Rosa ; Dorantes-Barrón, Ana María ; Arrieta-Báez, Daniel ; Gómez-Patiño, Mayra Beatriz ; Bernal-Trujillo, Andrea ; Castro-García, Mario ; Carro-Juárez, Miguel ; Martínez-Mota, Lucía. / Piper auritum Kunth (Piperaceae) improves the sexual performance of sluggish male rats through enhancing ejaculation. In: Journal of Ethnopharmacology. 2019 ; pp. 453-463.
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abstract = "{\circledC} 2018 Elsevier B.V. Ethnopharmacological relevance: Piper auritum Kunth is employed as an aphrodisiac in the traditional medicine, but corroborative evidence for such effect is scarce. Aim of the study: The pro-sexual effect of an aqueous extract of P. auritum and its possible mechanisms were analyzed in two paradigms of male sexual function. Material and methods: Effects of an aqueous extract of P. auritum (PA, single administration) were investigated in the fictive ejaculation, and copulatory behavior paradigms in sexually sluggish male rats. WAY 100635 (antagonist of 5-HT1A receptors), atosiban (antagonist of oxytocinergic receptors), L-NAME (inhibitor of the nitric oxide synthase) and baclofen (antagonist of GABAB receptors) were used as pre-treatments in order to investigate the role of different neurotransmitter systems in PA actions. Chemical profile of PA was determined by Gases Chromatography and Ultra Performance Chromatography-Electrospray Ionization-Masses Spectrometry (UPLC-ESI-MS). Results: In males with retarded ejaculation, PA stimulated ejaculatory behavior and recovered electromyographic activity of pelvic musculature participating in seminal emission and ejaculation. All pre-treatments blocked stimulating effects of PA on the fictive ejaculation; additionally WAY 100635 interfered with PA actions on ejaculatory behavior. Safrol, apigenin dimethylether, myristicin, vaccihein A, sakuranin and sakuranetin flavonoids, were main constituents of PA, with possible participation in its pro-sexual effects. Conclusions: Pro-sexual effects of P. auritum elicited at level of ejaculation were mediated by several neurotransmitter systems, among which serotonin and its 5-HT1A receptors play an important role. Present findings support P. auritum reputation as an aphrodisiac, with potential use in delayed ejaculation disorder.",
author = "Rosa Estrada-Reyes and Dorantes-Barr{\'o}n, {Ana Mar{\'i}a} and Daniel Arrieta-B{\'a}ez and G{\'o}mez-Pati{\~n}o, {Mayra Beatriz} and Andrea Bernal-Trujillo and Mario Castro-Garc{\'i}a and Miguel Carro-Ju{\'a}rez and Luc{\'i}a Mart{\'i}nez-Mota",
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Piper auritum Kunth (Piperaceae) improves the sexual performance of sluggish male rats through enhancing ejaculation. / Estrada-Reyes, Rosa; Dorantes-Barrón, Ana María; Arrieta-Báez, Daniel; Gómez-Patiño, Mayra Beatriz; Bernal-Trujillo, Andrea; Castro-García, Mario; Carro-Juárez, Miguel; Martínez-Mota, Lucía.

In: Journal of Ethnopharmacology, 01.03.2019, p. 453-463.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Piper auritum Kunth (Piperaceae) improves the sexual performance of sluggish male rats through enhancing ejaculation

AU - Estrada-Reyes, Rosa

AU - Dorantes-Barrón, Ana María

AU - Arrieta-Báez, Daniel

AU - Gómez-Patiño, Mayra Beatriz

AU - Bernal-Trujillo, Andrea

AU - Castro-García, Mario

AU - Carro-Juárez, Miguel

AU - Martínez-Mota, Lucía

PY - 2019/3/1

Y1 - 2019/3/1

N2 - © 2018 Elsevier B.V. Ethnopharmacological relevance: Piper auritum Kunth is employed as an aphrodisiac in the traditional medicine, but corroborative evidence for such effect is scarce. Aim of the study: The pro-sexual effect of an aqueous extract of P. auritum and its possible mechanisms were analyzed in two paradigms of male sexual function. Material and methods: Effects of an aqueous extract of P. auritum (PA, single administration) were investigated in the fictive ejaculation, and copulatory behavior paradigms in sexually sluggish male rats. WAY 100635 (antagonist of 5-HT1A receptors), atosiban (antagonist of oxytocinergic receptors), L-NAME (inhibitor of the nitric oxide synthase) and baclofen (antagonist of GABAB receptors) were used as pre-treatments in order to investigate the role of different neurotransmitter systems in PA actions. Chemical profile of PA was determined by Gases Chromatography and Ultra Performance Chromatography-Electrospray Ionization-Masses Spectrometry (UPLC-ESI-MS). Results: In males with retarded ejaculation, PA stimulated ejaculatory behavior and recovered electromyographic activity of pelvic musculature participating in seminal emission and ejaculation. All pre-treatments blocked stimulating effects of PA on the fictive ejaculation; additionally WAY 100635 interfered with PA actions on ejaculatory behavior. Safrol, apigenin dimethylether, myristicin, vaccihein A, sakuranin and sakuranetin flavonoids, were main constituents of PA, with possible participation in its pro-sexual effects. Conclusions: Pro-sexual effects of P. auritum elicited at level of ejaculation were mediated by several neurotransmitter systems, among which serotonin and its 5-HT1A receptors play an important role. Present findings support P. auritum reputation as an aphrodisiac, with potential use in delayed ejaculation disorder.

AB - © 2018 Elsevier B.V. Ethnopharmacological relevance: Piper auritum Kunth is employed as an aphrodisiac in the traditional medicine, but corroborative evidence for such effect is scarce. Aim of the study: The pro-sexual effect of an aqueous extract of P. auritum and its possible mechanisms were analyzed in two paradigms of male sexual function. Material and methods: Effects of an aqueous extract of P. auritum (PA, single administration) were investigated in the fictive ejaculation, and copulatory behavior paradigms in sexually sluggish male rats. WAY 100635 (antagonist of 5-HT1A receptors), atosiban (antagonist of oxytocinergic receptors), L-NAME (inhibitor of the nitric oxide synthase) and baclofen (antagonist of GABAB receptors) were used as pre-treatments in order to investigate the role of different neurotransmitter systems in PA actions. Chemical profile of PA was determined by Gases Chromatography and Ultra Performance Chromatography-Electrospray Ionization-Masses Spectrometry (UPLC-ESI-MS). Results: In males with retarded ejaculation, PA stimulated ejaculatory behavior and recovered electromyographic activity of pelvic musculature participating in seminal emission and ejaculation. All pre-treatments blocked stimulating effects of PA on the fictive ejaculation; additionally WAY 100635 interfered with PA actions on ejaculatory behavior. Safrol, apigenin dimethylether, myristicin, vaccihein A, sakuranin and sakuranetin flavonoids, were main constituents of PA, with possible participation in its pro-sexual effects. Conclusions: Pro-sexual effects of P. auritum elicited at level of ejaculation were mediated by several neurotransmitter systems, among which serotonin and its 5-HT1A receptors play an important role. Present findings support P. auritum reputation as an aphrodisiac, with potential use in delayed ejaculation disorder.

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