Pharmacological and histological study in diabetic rats with Asclepias glaucescens HBK treated

Julieta Herrera M, Blanca M. Berdeja M, Ma Estela Meléndez C, Ma Eugenia Ordorica V

Research output: Contribution to journalScientific review

Abstract

Asclepias glaucescens, Asclepidaceae plant is used as hypoglycemic agent in the State of Veracruz, Mexico. Gymnema sylvestre, of the same family, presents the same therapeutic effect in patients with type II diabetes, and it was reported that it regenerates the β cells of the pancreatic islets of Langerhans in diabetic rats. Therefore, the purpose of this study was to accomplish the phytochemical analysis of Asclepias glaucescens collected from Malinalco, State of Mexico and to determine its possible hypoglycemic activity in alloxan diabetic Wistar rats. The phytochemical analysis demonstrated the presence of alkaloids, flavonoids, cardiac glycosides, tannins and sugars. The plant did not offset the hyperglycemia present in rats, caused by the aloxana, and there was not any regeneration of the β cells (insulin producers) in the Langerhans islets. On the other hand the citotoxic effects of its metabolites were observed in heart and lungs, so we do not recommend the oral use of ethanolic extract of Asclepias glaucescens for therapeutic treatments.
Original languageAmerican English
Pages (from-to)26-30
Number of pages22
JournalRevista Mexicana de Ciencias Farmaceuticas
StatePublished - 1 Jan 2002

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Asclepias
Islets of Langerhans
rats
Rats
Mexico
Phytochemicals
Pharmacology
Hypoglycemic Agents
alloxan
Gymnema sylvestre
hyperglycemia
Tannins
Glycosides
Flavonoids
Cardiac Glycosides
Alkaloids
glucosides
insulin
Alloxan
alkaloids

Cite this

@article{6f82a1bf09404789bd22eb3d2247d804,
title = "Pharmacological and histological study in diabetic rats with Asclepias glaucescens HBK treated",
abstract = "Asclepias glaucescens, Asclepidaceae plant is used as hypoglycemic agent in the State of Veracruz, Mexico. Gymnema sylvestre, of the same family, presents the same therapeutic effect in patients with type II diabetes, and it was reported that it regenerates the β cells of the pancreatic islets of Langerhans in diabetic rats. Therefore, the purpose of this study was to accomplish the phytochemical analysis of Asclepias glaucescens collected from Malinalco, State of Mexico and to determine its possible hypoglycemic activity in alloxan diabetic Wistar rats. The phytochemical analysis demonstrated the presence of alkaloids, flavonoids, cardiac glycosides, tannins and sugars. The plant did not offset the hyperglycemia present in rats, caused by the aloxana, and there was not any regeneration of the β cells (insulin producers) in the Langerhans islets. On the other hand the citotoxic effects of its metabolites were observed in heart and lungs, so we do not recommend the oral use of ethanolic extract of Asclepias glaucescens for therapeutic treatments.",
author = "{Herrera M}, Julieta and {Berdeja M}, {Blanca M.} and {Mel{\'e}ndez C}, {Ma Estela} and {Ordorica V}, {Ma Eugenia}",
year = "2002",
month = "1",
day = "1",
language = "American English",
pages = "26--30",
journal = "Revista Mexicana de Ciencias Farmaceuticas",
issn = "1027-3956",
publisher = "Asociacion Farmaceutica Mexicana A.C.",

}

Pharmacological and histological study in diabetic rats with Asclepias glaucescens HBK treated. / Herrera M, Julieta; Berdeja M, Blanca M.; Meléndez C, Ma Estela; Ordorica V, Ma Eugenia.

In: Revista Mexicana de Ciencias Farmaceuticas, 01.01.2002, p. 26-30.

Research output: Contribution to journalScientific review

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AU - Berdeja M, Blanca M.

AU - Meléndez C, Ma Estela

AU - Ordorica V, Ma Eugenia

PY - 2002/1/1

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N2 - Asclepias glaucescens, Asclepidaceae plant is used as hypoglycemic agent in the State of Veracruz, Mexico. Gymnema sylvestre, of the same family, presents the same therapeutic effect in patients with type II diabetes, and it was reported that it regenerates the β cells of the pancreatic islets of Langerhans in diabetic rats. Therefore, the purpose of this study was to accomplish the phytochemical analysis of Asclepias glaucescens collected from Malinalco, State of Mexico and to determine its possible hypoglycemic activity in alloxan diabetic Wistar rats. The phytochemical analysis demonstrated the presence of alkaloids, flavonoids, cardiac glycosides, tannins and sugars. The plant did not offset the hyperglycemia present in rats, caused by the aloxana, and there was not any regeneration of the β cells (insulin producers) in the Langerhans islets. On the other hand the citotoxic effects of its metabolites were observed in heart and lungs, so we do not recommend the oral use of ethanolic extract of Asclepias glaucescens for therapeutic treatments.

AB - Asclepias glaucescens, Asclepidaceae plant is used as hypoglycemic agent in the State of Veracruz, Mexico. Gymnema sylvestre, of the same family, presents the same therapeutic effect in patients with type II diabetes, and it was reported that it regenerates the β cells of the pancreatic islets of Langerhans in diabetic rats. Therefore, the purpose of this study was to accomplish the phytochemical analysis of Asclepias glaucescens collected from Malinalco, State of Mexico and to determine its possible hypoglycemic activity in alloxan diabetic Wistar rats. The phytochemical analysis demonstrated the presence of alkaloids, flavonoids, cardiac glycosides, tannins and sugars. The plant did not offset the hyperglycemia present in rats, caused by the aloxana, and there was not any regeneration of the β cells (insulin producers) in the Langerhans islets. On the other hand the citotoxic effects of its metabolites were observed in heart and lungs, so we do not recommend the oral use of ethanolic extract of Asclepias glaucescens for therapeutic treatments.

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