Pharmacokinetics of oral ranitidine in Mexicans

G. Castaneda-Hernandez, F. J. Flores-Murrieta, V. Granados-Soto, A. Herrera-Abarca, J. Perez-Urizar, J. E. Herrera, E. Hong

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The pharmacokinetics of oral ranitidine were studied in 24 Mexican male healthy volunteers. Subjects received a tablet containing 150 mg of ranitidine (Azantac®, Glaxo de Mexico, Mexico City) after an overnight fast and blood samples were drawn at several times for a period of 24 h. Ranitidine concentration in plasma was measured by high performance liquid chromatography and pharmacokinetic parameters were determined by non-compartmental analysis. Ranitidine plasma concentration increased with time, reaching a maximum of (mean ± SEM) 484 ± 34 ng/ml in 2.7 ± 0.2 h. Plasma levels then decayed with a terminal half-life of 4.8 ± 0.3 h. The area under the plasma concentration against time curve was 2440 ± 126 ng.h/ml. Oral ranitidine pharmacokinetic parameters in Mexicans appeared to be similar to those previously reported for Caucasians.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalArchives of Medical Research
Volume27
Issue number3
StatePublished - 1996
Externally publishedYes

Keywords

  • Mexicans
  • Pharmacokinetics
  • Ranitidine

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