Abstract
The pharmacokinetics of ketorolac, a potent analgesic agent used for relief of moderate to severe pain, has been studied in rats who received oral doses of 1, 3.2 or 5.6 mg/kg of ketorolac tromethamine. Blood samples were obtained at selected times during 24 h after medication, and ketorolac concentrations were determined by high performance liquid chromatography. After administration of ketorolac, blood concentrations increased rapidly reaching a dose-dependent maximal concentration in about 20 min. Then, concentrations decayed with a half-life of about 6 h. A linear increase in C(max) and AUC as a function of the dose was observed, and no statistically signifcant difference was observed in AUC/dose or C(max)/dose between doses, indicating that pharmacokinetics of ketorolac is linear in the range of doses studied.
Original language | English |
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Pages (from-to) | 535-538 |
Number of pages | 4 |
Journal | Methods and Findings in Experimental and Clinical Pharmacology |
Volume | 17 |
Issue number | 8 |
State | Published - 1995 |
Externally published | Yes |
Keywords
- ketorolac tromethamine
- pharmacokinetics
- rat