Perezone and its isomer isoperezone induce caspase-dependent and caspase-independent cell death

L. E. Sánchez-Torres, J. A. Torres-Martínez, M. Godínez-Victoria, J. M. Omar, B. Velasco-Bejarano

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In this study, we investigated the cytotoxic effect of perezone, a constituent isolated from the roots of Perezia spp. and of its synthetic isomer isoperezone on the K562 human leukemia cell line. Perezone showed greater cytotoxic effect than isoperezone but both compounds were found to induce cytotoxicity trough a caspase-dependent and a caspase-independent mechanisms; important changes in their light scattering properties, phosphatidylserine translocation and mitochondrial membrane potential disruption were detected by cytometry. The mechanism of death induction of each compound showed interesting concentration-dependent differences. Neither compound induced the apoptosis inducing factor. © 2009 Elsevier GmbH. All rights reserved.
Original languageAmerican English
Pages (from-to)614-620
Number of pages551
JournalPhytomedicine
DOIs
StatePublished - 1 Jul 2010

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Caspases
Cell Death
Apoptosis Inducing Factor
Mitochondrial Membrane Potential
Phosphatidylserines
Leukemia
Light
Cell Line
isoperezone
perezone

Cite this

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title = "Perezone and its isomer isoperezone induce caspase-dependent and caspase-independent cell death",
abstract = "In this study, we investigated the cytotoxic effect of perezone, a constituent isolated from the roots of Perezia spp. and of its synthetic isomer isoperezone on the K562 human leukemia cell line. Perezone showed greater cytotoxic effect than isoperezone but both compounds were found to induce cytotoxicity trough a caspase-dependent and a caspase-independent mechanisms; important changes in their light scattering properties, phosphatidylserine translocation and mitochondrial membrane potential disruption were detected by cytometry. The mechanism of death induction of each compound showed interesting concentration-dependent differences. Neither compound induced the apoptosis inducing factor. {\circledC} 2009 Elsevier GmbH. All rights reserved.",
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Perezone and its isomer isoperezone induce caspase-dependent and caspase-independent cell death. / Sánchez-Torres, L. E.; Torres-Martínez, J. A.; Godínez-Victoria, M.; Omar, J. M.; Velasco-Bejarano, B.

In: Phytomedicine, 01.07.2010, p. 614-620.

Research output: Contribution to journalArticle

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T1 - Perezone and its isomer isoperezone induce caspase-dependent and caspase-independent cell death

AU - Sánchez-Torres, L. E.

AU - Torres-Martínez, J. A.

AU - Godínez-Victoria, M.

AU - Omar, J. M.

AU - Velasco-Bejarano, B.

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AB - In this study, we investigated the cytotoxic effect of perezone, a constituent isolated from the roots of Perezia spp. and of its synthetic isomer isoperezone on the K562 human leukemia cell line. Perezone showed greater cytotoxic effect than isoperezone but both compounds were found to induce cytotoxicity trough a caspase-dependent and a caspase-independent mechanisms; important changes in their light scattering properties, phosphatidylserine translocation and mitochondrial membrane potential disruption were detected by cytometry. The mechanism of death induction of each compound showed interesting concentration-dependent differences. Neither compound induced the apoptosis inducing factor. © 2009 Elsevier GmbH. All rights reserved.

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