PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response

Nuriban Valero-Pacheco, Lourdes Arriaga-Pizano, Eduardo Ferat-Osorio, Luz María Mora-Velandia, Rodolfo Pastelin-Palacios, Miguel Ángel Villasís-Keever, Celia Alpuche-Aranda, Luvia Enid Sánchez-Torres, Armando Isibasi, Laura Bonifaz, Constantino López-Macías

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23 Scopus citations

Abstract

PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored. We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8+ T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8+ T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus.

Original languageEnglish
Article number989673
JournalClinical and Developmental Immunology
Volume2013
DOIs
StatePublished - 2013

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