TY - JOUR
T1 - PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response
AU - Valero-Pacheco, Nuriban
AU - Arriaga-Pizano, Lourdes
AU - Ferat-Osorio, Eduardo
AU - Mora-Velandia, Luz María
AU - Pastelin-Palacios, Rodolfo
AU - Villasís-Keever, Miguel Ángel
AU - Alpuche-Aranda, Celia
AU - Sánchez-Torres, Luvia Enid
AU - Isibasi, Armando
AU - Bonifaz, Laura
AU - López-Macías, Constantino
PY - 2013
Y1 - 2013
N2 - PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored. We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8+ T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8+ T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus.
AB - PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored. We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8+ T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8+ T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus.
UR - http://www.scopus.com/inward/record.url?scp=84885674559&partnerID=8YFLogxK
U2 - 10.1155/2013/989673
DO - 10.1155/2013/989673
M3 - Artículo
C2 - 24187568
SN - 1740-2522
VL - 2013
JO - Clinical and Developmental Immunology
JF - Clinical and Developmental Immunology
M1 - 989673
ER -