Participation of voltage-dependent calcium channels in the development of epilepsy

Jesús Servando Medel Matus, Fernando Rafael Ramos Morales, José Correa Basurto, Jesús Samuel Cruz Sánchez, Margarita Virginia Saavedra Vélez, Vicente Velásquez Melgarejo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Epilepsy is de3ned as a chronic condition produced by different etiologies, characterized by the repetition of crises due to an excessive discharge of the cerebral neurons associated with clinical symptoms. It responds to a fast ion depolarization in a population of abnormal neurons. Causes of epilepsy are: genetic alterations, perinatal anoxia, traumatisms, tumors, congenital malformations, metabolic alterations, drug poisonings, and infections of the nervous system. Epileptic seizure is the transitory occurrence of signs and abnormal symptoms caused by excessive or synchronous neuronal activity, whereas, epilepsy is characterized by a permanent predisposition to generate seizures. During depolarization of neuronal membrane, calcium ions play an important role because they are intracellular messengers that regulate functions like: neurotransmitter release, neurosecretion, neuronal excitation, neuron survival and gene expression regulation . The in4ux of calcium through the plasmatic membrane represents a way to control intracellular calcium level. The mechanism of the entrance of calcium to the neuron is little known, but understanding the structure, function and regulation of voltagegated calcium channels is of remarkable progress.
Original languageAmerican English
Pages (from-to)329-335
Number of pages295
JournalActa Bioquimica Clinica Latinoamericana
StatePublished - 1 Jul 2010

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Calcium Channels
Neurons
Epilepsy
Calcium
Depolarization
Gene expression regulation
Neurotoxicity Syndromes
Neurosecretion
Ions
Membranes
Gene Expression Regulation
Neurology
Signs and Symptoms
Neurotransmitter Agents
Tumors
Seizures
Infection
Pharmaceutical Preparations
Population
Neoplasms

Cite this

Matus, J. S. M., Morales, F. R. R., Basurto, J. C., Sánchez, J. S. C., Vélez, M. V. S., & Melgarejo, V. V. (2010). Participation of voltage-dependent calcium channels in the development of epilepsy. Acta Bioquimica Clinica Latinoamericana, 329-335.
Matus, Jesús Servando Medel ; Morales, Fernando Rafael Ramos ; Basurto, José Correa ; Sánchez, Jesús Samuel Cruz ; Vélez, Margarita Virginia Saavedra ; Melgarejo, Vicente Velásquez. / Participation of voltage-dependent calcium channels in the development of epilepsy. In: Acta Bioquimica Clinica Latinoamericana. 2010 ; pp. 329-335.
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Matus, JSM, Morales, FRR, Basurto, JC, Sánchez, JSC, Vélez, MVS & Melgarejo, VV 2010, 'Participation of voltage-dependent calcium channels in the development of epilepsy', Acta Bioquimica Clinica Latinoamericana, pp. 329-335.

Participation of voltage-dependent calcium channels in the development of epilepsy. / Matus, Jesús Servando Medel; Morales, Fernando Rafael Ramos; Basurto, José Correa; Sánchez, Jesús Samuel Cruz; Vélez, Margarita Virginia Saavedra; Melgarejo, Vicente Velásquez.

In: Acta Bioquimica Clinica Latinoamericana, 01.07.2010, p. 329-335.

Research output: Contribution to journalArticle

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