Participation of K+channels in the endothelium-dependent and endothelium-independent components of the relaxant effect of rosuvastatin in rat aortic rings

Jorge López, Roberto Mendoza, Guadalupe Cleva Villanueva, Gustavo Martínez, Enrique F. Castillo, Carlos Castillo

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Rosuvastatin was tested on rat aortic rings in the presence and absence of K+channel blockers, mevalonic acid, and inhibitors of nitric oxide, prostaglandins, or endothelial-derived hyperpolarizing factor synthesis. The direct vascular effects of rosuvastatin were then evaluated by obtaining dose-response curves. Rosuvastatin relaxed aortic rings with and, to a lesser degree, without endothelium. Under both these conditions this effect was partially inhibited by L-NAME, tetraethylammonium, apamin + charybdotoxin (only administered together), or mevalonic acid. The combination of L-NAME with any of the other 3 treatments completely inhibited the effect of rosuvastatin, but indomethacin, clotrimazol, glibenclamide, charybdotoxin, or apamin alone had no effect. Therefore, the relaxation induced by rosuvastatin, even in the absence of endothelium, is partially related to 2 different mechanisms, one that is isoprenoid dependent and NO mediated and the other that is tied to the opening of Ca2+-dependent K+channels of the slow subfamily. © 2008 Sage Publications.
Original languageAmerican English
Pages (from-to)207-213
Number of pages185
JournalJournal of Cardiovascular Pharmacology and Therapeutics
DOIs
StatePublished - 1 Sep 2008
Externally publishedYes

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