TY - JOUR
T1 - Oxidative stress, mitochondrial function and adaptation to exercise
T2 - New perspectives in nutrition
AU - Vargas-Mendoza, Nancy
AU - Angeles-Valencia, Marcelo
AU - Morales-González, Ángel
AU - Madrigal-Santillán, Eduardo Osiris
AU - Morales-Martínez, Mauricio
AU - Madrigal-Bujaidar, Eduardo
AU - Álvarez-González, Isela
AU - Gutiérrez-Salinas, José
AU - Esquivel-Chirino, César
AU - Chamorro-Cevallos, Germán
AU - Cristóbal-Luna, José Melesio
AU - Morales-González, José A.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11
Y1 - 2021/11
N2 - Cells have the ability to adapt to stressful environments as a part of their evolution. Physical exercise induces an increase of a demand for energy that must be met by mitochondria as the main (ATP) provider. However, this process leads to the increase of free radicals and the so-called reactive oxygen species (ROS), which are necessary for the maintenance of cell signaling and homeostasis. In addition, mitochondrial biogenesis is influenced by exercise in continuous crosstalk between the mitochondria and the nuclear genome. Excessive workloads may induce severe mitochondrial stress, resulting in oxidative damage. In this regard, the objective of this work was to provide a general overview of the molecular mechanisms involved in mitochondrial adaptation during exercise and to understand if some nutrients such as antioxidants may be implicated in blunt adaptation and/or an impact on the performance of exercise by different means.
AB - Cells have the ability to adapt to stressful environments as a part of their evolution. Physical exercise induces an increase of a demand for energy that must be met by mitochondria as the main (ATP) provider. However, this process leads to the increase of free radicals and the so-called reactive oxygen species (ROS), which are necessary for the maintenance of cell signaling and homeostasis. In addition, mitochondrial biogenesis is influenced by exercise in continuous crosstalk between the mitochondria and the nuclear genome. Excessive workloads may induce severe mitochondrial stress, resulting in oxidative damage. In this regard, the objective of this work was to provide a general overview of the molecular mechanisms involved in mitochondrial adaptation during exercise and to understand if some nutrients such as antioxidants may be implicated in blunt adaptation and/or an impact on the performance of exercise by different means.
KW - Antioxidants
KW - Exercise
KW - Exercise performance
KW - Mitochondrial adaptation
KW - Oxidative damage
KW - Oxidative stress
KW - ROS/RNS
UR - http://www.scopus.com/inward/record.url?scp=85120057916&partnerID=8YFLogxK
U2 - 10.3390/life11111269
DO - 10.3390/life11111269
M3 - Artículo de revisión
C2 - 34833151
AN - SCOPUS:85120057916
SN - 2075-1729
VL - 11
JO - Life
JF - Life
IS - 11
M1 - 1269
ER -