Oxidative stress induced in Hyalella azteca by an effluent from a NSAID-manufacturing plant in Mexico

Karen Adriana Novoa-Luna, Rubí Romero-Romero, Reyna Natividad-Rangel, Marcela Galar-Martínez, Nely SanJuan-Reyes, Sandra García-Medina, Catalina Martínez-Vieyra, Nadia Neri-Cruz, Leobardo Manuel Gómez-Oliván

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© 2016, Springer Science+Business Media New York. Production in the pharmaceutical industry has increased and along with it, the amount of wastewater of various characteristics and contaminant concentrations. The main chemicals in these effluents are solvents, detergents, disinfectants—such as sodium hypochlorite (NaClO)—and pharmaceutical products, all of which are potentially ecotoxic. Therefore, this study aimed to evaluate the oxidative stress induced in the amphipod Hyalella azteca by the effluent from a nonsteroidal anti-inflammatory drug (NSAID)-manufacturing plant. The median lethal concentration (72 h-LC50) was determined and H. azteca were exposed to the lowest observed adverse effect level (0.0732 %) for 12, 24, 48 and 72 h, and biomarkers of oxidative stress were evaluated [hydroperoxide content (HPC), lipid peroxidation (LPX), protein carbonyl content (PCC), and the activity of the superoxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)]. Statistically significant increases with respect to the control group (P < 0.05) were observed in HPC, LPX and PCC in H. azteca at all exposure times. Antioxidant enzymes activity SOD, CAT and GPx activity also increased significantly (P < 0.05) with respect to the control group. In conclusion, the industrial effluent analyzed in the present study contains NSAIDs and NaClO, and induces oxidative stress in H. azteca.
Original languageAmerican English
Pages (from-to)1288-1304
Number of pages1157
StatePublished - 1 Sep 2016


Cite this

Novoa-Luna, K. A., Romero-Romero, R., Natividad-Rangel, R., Galar-Martínez, M., SanJuan-Reyes, N., García-Medina, S., Martínez-Vieyra, C., Neri-Cruz, N., & Gómez-Oliván, L. M. (2016). Oxidative stress induced in Hyalella azteca by an effluent from a NSAID-manufacturing plant in Mexico. Ecotoxicology, 1288-1304. https://doi.org/10.1007/s10646-016-1682-2