Organocatalysis: Trends of drug synthesis in medicinal chemistry

Background: The continuous increase in challenges associated with the effective treatment of life threatening diseases influences the development of drug therapies with suitable physicochemical properties, efficiency and selectivity. So, organocatalysis is a potential synthetic tool which is accelerating the development of new drug molecules. Methods: Organocatalysis reactions can be carried out at lower temperatures and in milder pH conditions as compared to metal based catalysed reactions. Due to ready availability of catalysts, stability, purity, low toxicity and easy in handling of the chemical reactions, it has become an attractive technique to synthesise complex molecules with diverse structures. Here, the impact of various catalysts in organic synthesis with methods is discussed. Results: Organic catalysts are used widely in various chemical reactions such as Michael Addition, aldol reaction, Diels-Alder reactions and Knoevenagal reactions. It was observed that the use of organocatalyst results in the formation of stereo active molecules with diverse biological activities. Conclusion: This review also focuses on the various scopes and limitations of organocatalytic reactions in the production of medicinally useful drug molecules. Organocatalysts possess several advantages over traditional metal catalysts because they are non-toxic, readily available, stable, efficient, and easy to handle which involves environmentally friendly reaction.