TY - JOUR
T1 - Oral pharmacokinetics of meloxicam in the rat using a high-performance liquid chromatography method in micro-whole-blood samples
AU - Aguilar-Mariscal, H.
AU - Patiño-Camacho, S. I.
AU - Rodríguez-Silverio, J.
AU - Torres-López, J. E.
AU - Flores-Murrieta, Francisco Javier
PY - 2007/11
Y1 - 2007/11
N2 - The pharmacokinetics of meloxicam, a potent analgesic and antiinflammatory drug used in several rheumatic diseases, has been studied in rats that received oral doses of 3.2, 5.6 or 10 mg/kg of meloxicam. Blood samples were obtained at selected times during 24 h after administration, and meloxicam concentrations were determined by a validated high-performance liquid chromatography (HPLC) method, using micro-whole-blood samples, developed in our laboratory. After administration of meloxicam, blood concentrations increased reaching a dose-dependent maximal concentration in about 2 h. Then, concentrations decayed with a half-life of 9 h. An increase in Cmax and AUC as a function of the dose was observed, and no statistically significant difference was observed in AUC/dose or Cmax/dose between doses. However, linearity could not be concluded because of the wide variability observed.
AB - The pharmacokinetics of meloxicam, a potent analgesic and antiinflammatory drug used in several rheumatic diseases, has been studied in rats that received oral doses of 3.2, 5.6 or 10 mg/kg of meloxicam. Blood samples were obtained at selected times during 24 h after administration, and meloxicam concentrations were determined by a validated high-performance liquid chromatography (HPLC) method, using micro-whole-blood samples, developed in our laboratory. After administration of meloxicam, blood concentrations increased reaching a dose-dependent maximal concentration in about 2 h. Then, concentrations decayed with a half-life of 9 h. An increase in Cmax and AUC as a function of the dose was observed, and no statistically significant difference was observed in AUC/dose or Cmax/dose between doses. However, linearity could not be concluded because of the wide variability observed.
KW - Meloxicam
KW - Pharmacokinetics
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=38749086181&partnerID=8YFLogxK
U2 - 10.1358/mf.2007.29.9.1116314
DO - 10.1358/mf.2007.29.9.1116314
M3 - Artículo
C2 - 18193109
SN - 0379-0355
VL - 29
SP - 587
EP - 591
JO - Methods and Findings in Experimental and Clinical Pharmacology
JF - Methods and Findings in Experimental and Clinical Pharmacology
IS - 9
ER -