Oral pharmacokinetics of meloxicam in the rat using a high-performance liquid chromatography method in micro-whole-blood samples

H. Aguilar-Mariscal, S. I. Patiño-Camacho, J. Rodríguez-Silverio, J. E. Torres-López, Francisco Javier Flores-Murrieta

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The pharmacokinetics of meloxicam, a potent analgesic and antiinflammatory drug used in several rheumatic diseases, has been studied in rats that received oral doses of 3.2, 5.6 or 10 mg/kg of meloxicam. Blood samples were obtained at selected times during 24 h after administration, and meloxicam concentrations were determined by a validated high-performance liquid chromatography (HPLC) method, using micro-whole-blood samples, developed in our laboratory. After administration of meloxicam, blood concentrations increased reaching a dose-dependent maximal concentration in about 2 h. Then, concentrations decayed with a half-life of 9 h. An increase in Cmax and AUC as a function of the dose was observed, and no statistically significant difference was observed in AUC/dose or Cmax/dose between doses. However, linearity could not be concluded because of the wide variability observed.

Original languageEnglish
Pages (from-to)587-591
Number of pages5
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume29
Issue number9
DOIs
StatePublished - Nov 2007

Keywords

  • Meloxicam
  • Pharmacokinetics
  • Rat

Fingerprint

Dive into the research topics of 'Oral pharmacokinetics of meloxicam in the rat using a high-performance liquid chromatography method in micro-whole-blood samples'. Together they form a unique fingerprint.

Cite this