TY - JOUR
T1 - Oral bovine lactoferrin modulation on fecal microbiota of mice underwent immobilization stress
AU - Efrain Molotla-Torres, Daniel
AU - Mario Hernández-Soto, Luis
AU - Guzmán-Mejía, Fabiola
AU - Godínez-Victoria, Marycarmen
AU - Elisa Drago-Serrano, Maria
AU - Félix Aguirre-Garrido, José
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/8
Y1 - 2022/8
N2 - Lactoferrin, a diferric-binding glycoprotein drives the abundance of some gut microbiota members, but its role under stress conditions is unknown thus this aspect was the aim of this contribution. Female BALB/c mice (n = 4/group), treated orally with lactoferrin for 7 days were either stressed by board-immobilization from the 4th-to-7th day of treatment (LS) or unstressed (L). Two groups provided with water and stressed (S) or unstressed (C) were included. On day 7, feces were collected for the massive sequencing of V4-V5 region of the 16S rDNA gene. Regarding C-group, the only significant changes were found in the L-group that showed an increased abundance in most taxa of the genus Bacteroides (Phylum Bacteroidetes) and Parasuterella (Phylum Proteobacteria) or decreased of Clostridium_XIVb (Phylum Firmicutes), Lactoferrin-associated microbiota changes may result from stress independent modulatory pathways. Data may provide experimental foundations for using lactoferrin as a therapeutic co-adjuvant for diseases like obesity with microbiome alterations.
AB - Lactoferrin, a diferric-binding glycoprotein drives the abundance of some gut microbiota members, but its role under stress conditions is unknown thus this aspect was the aim of this contribution. Female BALB/c mice (n = 4/group), treated orally with lactoferrin for 7 days were either stressed by board-immobilization from the 4th-to-7th day of treatment (LS) or unstressed (L). Two groups provided with water and stressed (S) or unstressed (C) were included. On day 7, feces were collected for the massive sequencing of V4-V5 region of the 16S rDNA gene. Regarding C-group, the only significant changes were found in the L-group that showed an increased abundance in most taxa of the genus Bacteroides (Phylum Bacteroidetes) and Parasuterella (Phylum Proteobacteria) or decreased of Clostridium_XIVb (Phylum Firmicutes), Lactoferrin-associated microbiota changes may result from stress independent modulatory pathways. Data may provide experimental foundations for using lactoferrin as a therapeutic co-adjuvant for diseases like obesity with microbiome alterations.
KW - Bovine lactoferrin
KW - Dysbiosis
KW - Immobilization stress
KW - Intestinal homeostasis
KW - Microbiota
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85133918109&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2022.105153
DO - 10.1016/j.jff.2022.105153
M3 - Artículo
AN - SCOPUS:85133918109
SN - 1756-4646
VL - 95
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 105153
ER -