TY - JOUR
T1 - On the preparation and characterization of superparamagnetic nanoparticles with Gelidium robustum agar coating for biomedical applications
AU - Díaz-Bleis, Dianela
AU - Alvarado-Gil, Juan José
AU - Martínez, Arturo I.
AU - Gómez-Y-Gómez, Yolanda
AU - Freile-Pelegrín, Yolanda
N1 - Publisher Copyright:
© Indian Academy of Sciences.
PY - 2018/4
Y1 - 2018/4
N2 - Superparamagnetic nanoparticles coated with natural polysaccharides are of great interest for biomedical applications due to their fast response to an external and high-frequency electromagnetic field and their biocompatibility. One of the greatest challenges in the development of these nanoparticles is related to the specific characteristics and properties of the polysaccharide used, which could guarantee the development of specific sizes, crystalline structure, magnetic response and its reproducibility. In this study, we present the preparation of magnetite (Fe3O4) and cobalt ferrite (CoFe2O4) nanoparticles by the co-precipitation method in aqueous solutions at different concentrations (1, 2, 3, 4 and 5%) of a very well-characterized agar obtained from the red marine algae Gelidium robustum. It is shown that under the same experimental conditions and using the adequate precursors, coated high-crystallinity magnetite nanoparticles are obtained. In contrast, for cobalt ferrite, our results indicated the formation of coated low-crystallinity CoFe2O4 particles. Superparamagnetic nanoparticles (with crystal grain size <8 nm) of Fe3O4 agar coated at ≥3% agar showed high-saturation magnetization and high degree of biocompatibility and can be considered as promising candidates for biomedical applications.
AB - Superparamagnetic nanoparticles coated with natural polysaccharides are of great interest for biomedical applications due to their fast response to an external and high-frequency electromagnetic field and their biocompatibility. One of the greatest challenges in the development of these nanoparticles is related to the specific characteristics and properties of the polysaccharide used, which could guarantee the development of specific sizes, crystalline structure, magnetic response and its reproducibility. In this study, we present the preparation of magnetite (Fe3O4) and cobalt ferrite (CoFe2O4) nanoparticles by the co-precipitation method in aqueous solutions at different concentrations (1, 2, 3, 4 and 5%) of a very well-characterized agar obtained from the red marine algae Gelidium robustum. It is shown that under the same experimental conditions and using the adequate precursors, coated high-crystallinity magnetite nanoparticles are obtained. In contrast, for cobalt ferrite, our results indicated the formation of coated low-crystallinity CoFe2O4 particles. Superparamagnetic nanoparticles (with crystal grain size <8 nm) of Fe3O4 agar coated at ≥3% agar showed high-saturation magnetization and high degree of biocompatibility and can be considered as promising candidates for biomedical applications.
KW - Agar
KW - Cobalt ferrite
KW - Magnetite
KW - Superparamagnetic nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85075416377&partnerID=8YFLogxK
U2 - 10.1007/s12034-018-1546-x
DO - 10.1007/s12034-018-1546-x
M3 - Artículo
AN - SCOPUS:85075416377
SN - 0250-4707
VL - 41
JO - Bulletin of Materials Science
JF - Bulletin of Materials Science
IS - 2
M1 - 39
ER -