Obtaining symmetric and asymmetric bisphosphoramidates and bisphosphoramidothioates by a single step multicomponent reaction

Angel Zamudio-Medina, Nury Pérez-Hernández, José Luis Castrejón-Flores, Susana Romero-García, Heriberto Prado-García, Angel Bañuelos-Hernández, Marco Franco-Pérez

Research output: Contribution to journalArticlepeer-review

Abstract

We present a new single-step multicomponent reaction strategy for the synthesis of symmetric and (novel) asymmetric bisphosphoramidate and bisphosphoramidothioate derivatives. Reactions proceed under routine experimental conditions, do not require the aid of any catalyst, and provide moderate yields after a short time. We synthesized 18 different compounds, 10 of them for the first time. The cytotoxic activity of our adducts was assessed by measuring their inhibitory capacity (IC50) against two different cell lines, the A549 (lung cancer cells) and the SW1353 (chondrosarcoma cells).

Original languageEnglish
Pages (from-to)634-642
Number of pages9
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume196
Issue number7
DOIs
StatePublished - 2021

Keywords

  • bisphosphoramidates
  • bisphosphoramidothioates
  • cytotoxicity
  • double addition–elimination
  • Multicomponent reaction
  • symmetric and asymmetric derivatives

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