TY - JOUR
T1 - Obesity phenotypes in urban middle-class cohorts; the PRIT-Lindavista merging evidence in Mexico
T2 - The OPUS PRIME study
AU - Fanghänel-Salmón, Guillermo
AU - Gutiérrez-Salmeán, Gabriela
AU - Samaniego, Virginia
AU - Meaney, Alejandra
AU - Sánchez-Reyes, Leticia
AU - Navarrete, Ulises
AU - Alcocer, Luis
AU - Olivares-Corichi, Ivonne
AU - Najera, Nayeli
AU - Ceballos, Guillermo
AU - Meaney, Eduardo
N1 - Publisher Copyright:
© 2015, Grupo Aula Medica S.A. All rights reserved.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background and aims: even though overweight and obesity (O/O) are stated diseases, there is still a claim for a so-called “healthy obese” phenotype. Only few reports have explored the presence of different metabolic phenotypes along the body mass index (BMI) range and their corresponding associations to cardiovascular risks. Methods: as of BMI, and according to the presence of metabolic syndrome (MS) features (waist circumference, blood pressure, fasting glycemia, and lipid profile), phenotypes were determined. Cardiovascular risk was estimated with atherogenic quotients: total cholesterol/ HDL-c, LDL-c/HDL-c and the triglycerides (TG)/HDL-c index. Results: in 8 405 mexican adults, 36% lean, 43% overweighed and 21% obese, nine phenotypes were identified: for each weight category there were subjects with normal metabolism (none MS factors), intermediate (≤ 2) and dysmetabolic (≥ 3). Only 10.8% of O/O had normal metabolism, and 5.8% of the lean persons were dysmetabolic. Atherogenic risk was higher in dysmetabolic obese persons, but the risk was high among all dysmetabolic people, independently of the weight status. TG/HDL-c showed the same trend. Conclusions: elevated cardiometabolic risk derives from the high prevalence of O/O. A great proportion of non-obese people have intermediate dysmetabolism. A genetic predisposition to obesity, insulin resistance, diabetes and dyslipidemia in Mexican population is blendedto an unhealthy lifestyle, yielding to a catastrophic epidemic of diabetes, and cardiovascular diseases.
AB - Background and aims: even though overweight and obesity (O/O) are stated diseases, there is still a claim for a so-called “healthy obese” phenotype. Only few reports have explored the presence of different metabolic phenotypes along the body mass index (BMI) range and their corresponding associations to cardiovascular risks. Methods: as of BMI, and according to the presence of metabolic syndrome (MS) features (waist circumference, blood pressure, fasting glycemia, and lipid profile), phenotypes were determined. Cardiovascular risk was estimated with atherogenic quotients: total cholesterol/ HDL-c, LDL-c/HDL-c and the triglycerides (TG)/HDL-c index. Results: in 8 405 mexican adults, 36% lean, 43% overweighed and 21% obese, nine phenotypes were identified: for each weight category there were subjects with normal metabolism (none MS factors), intermediate (≤ 2) and dysmetabolic (≥ 3). Only 10.8% of O/O had normal metabolism, and 5.8% of the lean persons were dysmetabolic. Atherogenic risk was higher in dysmetabolic obese persons, but the risk was high among all dysmetabolic people, independently of the weight status. TG/HDL-c showed the same trend. Conclusions: elevated cardiometabolic risk derives from the high prevalence of O/O. A great proportion of non-obese people have intermediate dysmetabolism. A genetic predisposition to obesity, insulin resistance, diabetes and dyslipidemia in Mexican population is blendedto an unhealthy lifestyle, yielding to a catastrophic epidemic of diabetes, and cardiovascular diseases.
KW - Cardiovascular risk
KW - Metabolic phenotypes
KW - Metabolic syndrome
KW - Obesity
KW - Overweight
UR - http://www.scopus.com/inward/record.url?scp=84936768700&partnerID=8YFLogxK
U2 - 10.3305/nh.2015.32.1.8646
DO - 10.3305/nh.2015.32.1.8646
M3 - Artículo
C2 - 26262714
SN - 0212-1611
VL - 32
SP - 182
EP - 188
JO - Nutricion Hospitalaria
JF - Nutricion Hospitalaria
IS - 1
ER -