Numerical study of the hydrodynamic drag force in atomic force microscopy measurements undertaken in fluids

J. V. Méndez-Méndez, M. T. Alonso-Rasgado, E. Correia Faria, E. A. Flores-Johnson, R. D. Snook

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

When atomic force microscopy (AFM) is employed for in vivo study of immersed biological samples, the fluid medium presents additional complexities, not least of which is the hydrodynamic drag force due to viscous friction of the cantilever with the liquid. This force should be considered when interpreting experimental results and any calculated material properties. In this paper, a numerical model is presented to study the influence of the drag force on experimental data obtained from AFM measurements using computational fluid dynamics (CFD) simulation. The model provides quantification of the drag force in AFM measurements of soft specimens in fluids.The numerical predictions were compared with experimental data obtained using AFM with a V-shaped cantilever fitted with a pyramidal tip. Tip velocities ranging from 1.05 to 105. μm/s were employed in water, polyethylene glycol and glycerol with the platform approaching from a distance of 6000. nm. The model was also compared with an existing analytical model. Good agreement was observed between numerical results, experiments and analytical predictions. Accurate predictions were obtained without the need for extrapolation of experimental data. In addition, the model can be employed over the range of tip geometries and velocities typically utilized in AFM measurements. © 2014 Elsevier Ltd.
Original languageAmerican English
Pages (from-to)37-46
Number of pages32
JournalMicron
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

Fingerprint

Atomic Force Microscopy
Hydrodynamics
drag
Drag
Atomic force microscopy
hydrodynamics
atomic force microscopy
Fluids
fluids
predictions
Friction
computational fluid dynamics
glycerols
Glycerol
Extrapolation
Polyethylene glycols
glycols
polyethylenes
extrapolation
Numerical models

Cite this

Méndez-Méndez, J. V. ; Alonso-Rasgado, M. T. ; Correia Faria, E. ; Flores-Johnson, E. A. ; Snook, R. D. / Numerical study of the hydrodynamic drag force in atomic force microscopy measurements undertaken in fluids. In: Micron. 2014 ; pp. 37-46.
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Numerical study of the hydrodynamic drag force in atomic force microscopy measurements undertaken in fluids. / Méndez-Méndez, J. V.; Alonso-Rasgado, M. T.; Correia Faria, E.; Flores-Johnson, E. A.; Snook, R. D.

In: Micron, 01.01.2014, p. 37-46.

Research output: Contribution to journalArticle

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