TY - JOUR
T1 - New naphthalene-derivative as cardioprotector drug on the Ischemia/Reperfusion Injury
AU - Rosas-Nexticapa, Marcela
AU - Figueroa-Valverde, Lauro
AU - Díaz-Cedillo, Francisco
AU - Hau-Heredia, Lenin
AU - García-Cervera, Elodia
AU - Pool-Gómez, Eduardo
AU - García-Martínez, Rolando
AU - Amacho-Luis, Abelardo
PY - 2015/6/1
Y1 - 2015/6/1
N2 - There is scarce information about the effects exerted by the naphthalene derivatives on cardiac injury caused by ischemia/reperfusion. In this study, a new naphthalene derivative was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of the naphthalene derivative on ischemia/reperfusion injury. Additionally, molecular mechanism involved in the activity exerted by the naphthalene derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; propanolol, prazosin, metoprolol, indomethacin and nifedipine. The results showed that the naphthalene derivative reduces infarct size compared with control. Other results showed that the naphthalene derivative significantly increase (p = 0.05) the perfusion pressure and coronary resistance in isolated heart. In addition, other data indicate that the naphthalene derivative increase left ventricular pressure in a dose-dependent manner (0.001 to 100 nM); however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05). In conclusion, these data suggest that naphthalene derivative exert a cardioprotective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.
AB - There is scarce information about the effects exerted by the naphthalene derivatives on cardiac injury caused by ischemia/reperfusion. In this study, a new naphthalene derivative was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of the naphthalene derivative on ischemia/reperfusion injury. Additionally, molecular mechanism involved in the activity exerted by the naphthalene derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; propanolol, prazosin, metoprolol, indomethacin and nifedipine. The results showed that the naphthalene derivative reduces infarct size compared with control. Other results showed that the naphthalene derivative significantly increase (p = 0.05) the perfusion pressure and coronary resistance in isolated heart. In addition, other data indicate that the naphthalene derivative increase left ventricular pressure in a dose-dependent manner (0.001 to 100 nM); however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05). In conclusion, these data suggest that naphthalene derivative exert a cardioprotective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.
KW - Left ventricular pressure
KW - Naphthalene
KW - Nifedipine
UR - http://www.scopus.com/inward/record.url?scp=84940179139&partnerID=8YFLogxK
U2 - 10.13005/bpj/600
DO - 10.13005/bpj/600
M3 - Artículo
SN - 0974-6242
VL - 8
SP - 203
EP - 212
JO - Biomedical and Pharmacology Journal
JF - Biomedical and Pharmacology Journal
IS - 1
ER -