New naphthalene-derivative as cardioprotector drug on the Ischemia/Reperfusion Injury

Marcela Rosas-Nexticapa, Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, Lenin Hau-Heredia, Elodia García-Cervera, Eduardo Pool-Gómez, Rolando García-Martínez, Abelardo Amacho-Luis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

There is scarce information about the effects exerted by the naphthalene derivatives on cardiac injury caused by ischemia/reperfusion. In this study, a new naphthalene derivative was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of the naphthalene derivative on ischemia/reperfusion injury. Additionally, molecular mechanism involved in the activity exerted by the naphthalene derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; propanolol, prazosin, metoprolol, indomethacin and nifedipine. The results showed that the naphthalene derivative reduces infarct size compared with control. Other results showed that the naphthalene derivative significantly increase (p = 0.05) the perfusion pressure and coronary resistance in isolated heart. In addition, other data indicate that the naphthalene derivative increase left ventricular pressure in a dose-dependent manner (0.001 to 100 nM); however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05). In conclusion, these data suggest that naphthalene derivative exert a cardioprotective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.
Original languageAmerican English
Pages (from-to)203-212
Number of pages181
JournalBiomedical and Pharmacology Journal
DOIs
StatePublished - 1 Jan 2015

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Reperfusion Injury
Pharmaceutical Preparations
Ventricular Pressure
Nifedipine
Perfusion
Pressure
Metoprolol
naphthalene
Prazosin
Calcium Channels
Propranolol
Indomethacin
Reperfusion
Necrosis
Ischemia

Cite this

Rosas-Nexticapa, M., Figueroa-Valverde, L., Díaz-Cedillo, F., Hau-Heredia, L., García-Cervera, E., Pool-Gómez, E., ... Amacho-Luis, A. (2015). New naphthalene-derivative as cardioprotector drug on the Ischemia/Reperfusion Injury. Biomedical and Pharmacology Journal, 203-212. https://doi.org/10.13005/bpj/600
Rosas-Nexticapa, Marcela ; Figueroa-Valverde, Lauro ; Díaz-Cedillo, Francisco ; Hau-Heredia, Lenin ; García-Cervera, Elodia ; Pool-Gómez, Eduardo ; García-Martínez, Rolando ; Amacho-Luis, Abelardo. / New naphthalene-derivative as cardioprotector drug on the Ischemia/Reperfusion Injury. In: Biomedical and Pharmacology Journal. 2015 ; pp. 203-212.
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Rosas-Nexticapa, M, Figueroa-Valverde, L, Díaz-Cedillo, F, Hau-Heredia, L, García-Cervera, E, Pool-Gómez, E, García-Martínez, R & Amacho-Luis, A 2015, 'New naphthalene-derivative as cardioprotector drug on the Ischemia/Reperfusion Injury', Biomedical and Pharmacology Journal, pp. 203-212. https://doi.org/10.13005/bpj/600

New naphthalene-derivative as cardioprotector drug on the Ischemia/Reperfusion Injury. / Rosas-Nexticapa, Marcela; Figueroa-Valverde, Lauro; Díaz-Cedillo, Francisco; Hau-Heredia, Lenin; García-Cervera, Elodia; Pool-Gómez, Eduardo; García-Martínez, Rolando; Amacho-Luis, Abelardo.

In: Biomedical and Pharmacology Journal, 01.01.2015, p. 203-212.

Research output: Contribution to journalArticle

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AU - Rosas-Nexticapa, Marcela

AU - Figueroa-Valverde, Lauro

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AU - Hau-Heredia, Lenin

AU - García-Cervera, Elodia

AU - Pool-Gómez, Eduardo

AU - García-Martínez, Rolando

AU - Amacho-Luis, Abelardo

PY - 2015/1/1

Y1 - 2015/1/1

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Rosas-Nexticapa M, Figueroa-Valverde L, Díaz-Cedillo F, Hau-Heredia L, García-Cervera E, Pool-Gómez E et al. New naphthalene-derivative as cardioprotector drug on the Ischemia/Reperfusion Injury. Biomedical and Pharmacology Journal. 2015 Jan 1;203-212. https://doi.org/10.13005/bpj/600