Abstract
A new synthetic approach is described for building the coumarin scaffold through the Lewis acid-promoted cyclization of novel aryl 3-(dimethylamino)prop- 2-enoates 2a - 2f. The latter precursors were prepared via aminomethylenation of the corresponding aryl acetates 4a - 4f with the Bredereck reagent. This approach was used for the synthesis of biologically active natural compounds 1a - 1f, through a three-step procedure starting from the corresponding phenols.
Original language | English |
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Pages (from-to) | 185-198 |
Number of pages | 14 |
Journal | Helvetica Chimica Acta |
Volume | 94 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2011 |