TY - JOUR
T1 - Neurophysiological mechanisms related to pain management in bone tumors
AU - Romero-Morelos, Pablo
AU - Ruvalcaba-Paredes, Erika
AU - Garciadiego-Cázares, David
AU - Pérez-Santos, Martín
AU - Reyes-Long, Samuel
AU - Alfaro-Rodriguez, Alfonso
AU - Salcedo, Mauricio
AU - Mancilla-Ramírez, Javier
AU - Bandala, Cindy
N1 - Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - Background: Primary and metastatic bone tumor incidence has increased in the previous years. Pain is a common symptom and is one of the most important related factors to the decrease of quality of life in patients with bone tumor. Different pain management strategies are not completely effective and many patients afflicted by cancer pain cannot be controlled properly. In this sense, we need to elucidate the neurophysiology of cancer-induced pain, contemplating other components such as inflammation, neuropathies and cognitive components regarding bone tumors, and thus pave the way for novel therapeutic approaches in this field. Aim: This study aims to identify the neurophysiology of the mechanisms related to pain management in bone tumors. Methods: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index to get information about the neurophysiology mechanisms related to pain management in bone tumors. Results: The central and peripheral mechanisms that promote bone cancer pain are poorly under-stood. Studies have shown that bone cancer could be related to neurochemicals produced by tumor and inflammatory cells, coupled with peripheral sensitization due to nerve compression and injury caused by tumor growth. The activity of mesolimbic dopaminergic neurons, substance P, cys-teine/glutamate antiporter, and other neurochemical dynamics brings us putative strategies to sug-gest better and efficient treatments against pain in cancer patients. Conclusion: Cancer-induced bone pain could include neuropathic and inflammatory pain, but with different modifications to the periphery tissue, nerves and neurochemical changes in different neurological levels. In this sense, we explore opportunity areas in pharmacological and non-pharmacological pain management, according to pain-involved mechanisms in this study.
AB - Background: Primary and metastatic bone tumor incidence has increased in the previous years. Pain is a common symptom and is one of the most important related factors to the decrease of quality of life in patients with bone tumor. Different pain management strategies are not completely effective and many patients afflicted by cancer pain cannot be controlled properly. In this sense, we need to elucidate the neurophysiology of cancer-induced pain, contemplating other components such as inflammation, neuropathies and cognitive components regarding bone tumors, and thus pave the way for novel therapeutic approaches in this field. Aim: This study aims to identify the neurophysiology of the mechanisms related to pain management in bone tumors. Methods: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index to get information about the neurophysiology mechanisms related to pain management in bone tumors. Results: The central and peripheral mechanisms that promote bone cancer pain are poorly under-stood. Studies have shown that bone cancer could be related to neurochemicals produced by tumor and inflammatory cells, coupled with peripheral sensitization due to nerve compression and injury caused by tumor growth. The activity of mesolimbic dopaminergic neurons, substance P, cys-teine/glutamate antiporter, and other neurochemical dynamics brings us putative strategies to sug-gest better and efficient treatments against pain in cancer patients. Conclusion: Cancer-induced bone pain could include neuropathic and inflammatory pain, but with different modifications to the periphery tissue, nerves and neurochemical changes in different neurological levels. In this sense, we explore opportunity areas in pharmacological and non-pharmacological pain management, according to pain-involved mechanisms in this study.
KW - Bone pain
KW - Neurological mechanism
KW - Neuropathic
KW - Nociceptive
KW - Novel management
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85102502828&partnerID=8YFLogxK
U2 - 10.2174/1570159X18666201111112748
DO - 10.2174/1570159X18666201111112748
M3 - Artículo de revisión
C2 - 33176655
AN - SCOPUS:85102502828
SN - 1570-159X
VL - 19
SP - 308
EP - 319
JO - Current Neuropharmacology
JF - Current Neuropharmacology
IS - 3
ER -