TY - JOUR
T1 - Neuropharmacological and toxicity evaluations of ethanol extract from Rhodiola rosea
AU - Montiel-Ruiz, Rosa Mariana
AU - Roa-Coria, José Eduardo
AU - Patiño-Camacho, Selene Isabel
AU - Flores-Murrieta, Francisco J.
AU - Déciga-Campos, Myrna
PY - 2012/3
Y1 - 2012/3
N2 - Strategy, Management and Health Policy Enabling Technology, Genomics, Proteomics Preclinical Research Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics Clinical Development Phases I-III Regulatory, Quality, Manufacturing Postmarketing Phase IV Rhodiola rosea is a popular medicinal plant that is commonly used as an adaptogen in folklore medicine in Europe and Asia due to its ability to increase an organism's resistance to physical, chemical and biological stress. The aim of this study was to determine the central nervous system activity and toxicity parameters of R. rosea. An ethanol extract from the roots of R. rosea was orally (p.o.) administered to mice (10-316 mg/kg); exploratory activity, anti-anxiety, behavior, sodium pentobarbital-induced hypnosis, antinociceptive effects, and pentylenetetrazole-induced seizures were tested. The results from the experimental models tested showed a significant reduction in exploratory behavior and in the number of rearings and head dippings, but no change in the sedative-hypnotic and anticonvulsant response with respect to vehicle. Moreover, R. rosea reduced the licking time in the formalin test. R. rosea was not toxic in Artemia salina and in mice. The present results confirm some preclinical and clinical studies that indicate stimulating, anxiolytic-like effects and present new evidence of the antinociceptive effect of and very low risk of toxicity from R. rosea.
AB - Strategy, Management and Health Policy Enabling Technology, Genomics, Proteomics Preclinical Research Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics Clinical Development Phases I-III Regulatory, Quality, Manufacturing Postmarketing Phase IV Rhodiola rosea is a popular medicinal plant that is commonly used as an adaptogen in folklore medicine in Europe and Asia due to its ability to increase an organism's resistance to physical, chemical and biological stress. The aim of this study was to determine the central nervous system activity and toxicity parameters of R. rosea. An ethanol extract from the roots of R. rosea was orally (p.o.) administered to mice (10-316 mg/kg); exploratory activity, anti-anxiety, behavior, sodium pentobarbital-induced hypnosis, antinociceptive effects, and pentylenetetrazole-induced seizures were tested. The results from the experimental models tested showed a significant reduction in exploratory behavior and in the number of rearings and head dippings, but no change in the sedative-hypnotic and anticonvulsant response with respect to vehicle. Moreover, R. rosea reduced the licking time in the formalin test. R. rosea was not toxic in Artemia salina and in mice. The present results confirm some preclinical and clinical studies that indicate stimulating, anxiolytic-like effects and present new evidence of the antinociceptive effect of and very low risk of toxicity from R. rosea.
KW - Rhodiola rosea
KW - antinociception
KW - anxiolytic effect
KW - central nervous system
UR - http://www.scopus.com/inward/record.url?scp=84859888672&partnerID=8YFLogxK
U2 - 10.1002/ddr.21001
DO - 10.1002/ddr.21001
M3 - Artículo
SN - 0272-4391
VL - 73
SP - 106
EP - 113
JO - Drug Development Research
JF - Drug Development Research
IS - 2
ER -